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Pan-cancer association of a mitochondrial function score with genomic alterations and clinical outcome.
Sci Rep
December 2024
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China.
Mitochondria are pivotal in cellular energy metabolism and have garnered significant attention for their roles in cancer progression and therapy resistance. Despite this, the functional diversity of mitochondria across various cancer types remains inadequately characterized. This study seeks to fill this knowledge gap by introducing and validating MitoScore-a novel metric designed to quantitatively assess mitochondrial function across a wide array of cancers.
View Article and Find Full Text PDFAssociation between the ratio of serum uric acid to high-density lipoprotein cholesterol and liver fat content: evidence from a Chinese health examination dataset.
Sci Rep
December 2024
Department of Health Management, Chronic Health Management Laboratory, Henan Provincial People's Hospital, Zhengzhou, 450003, China.
Despite numerous studies investigating the correlation between the serum uric acid and high-density lipoprotein cholesterol ratio (UHR) and fatty liver disease, the evidence for the dose-response relationship between UHR and liver fat content (LFC) remains uncertain. This study employs quantitative computed tomography (CT) to quantify LFC and aims to investigate the correlation and dose-response relationship between UHR levels and LFC in Chinese adults. Based on the health check-up data from 2021 at Henan Provincial People's Hospital, China, the objective of this cross-sectional study was to investigate the association between UHR levels and LFC among individuals of different genders.
View Article and Find Full Text PDFImpact of EV interfacing on peak-shelving and frequency regulation in a microgrid.
Sci Rep
December 2024
Department of Electrical Engineering, Dr.Shakuntala Misra National Rehabilitation University, Lucknow, India.
A vehicle-to-grid (V2G) technology enables bidirectional power exchange between electric vehicles (EVs) and the power grid, presenting enhanced grid stability and load management opportunities. This study investigates a comprehensive microgrid system integrating EVs with solar (8 MW), wind (4.5 MW), and diesel generation sources, focusing on peak load reduction and frequency regulation capabilities.
View Article and Find Full Text PDFInvestigating the association between labor pain and cessation of breastfeeding.
Sci Rep
December 2024
Department of Women's Anesthesia, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Mothers encounter several challenges to sustain breastfeeding until the recommended 6 months of age. There is limited evidence on the impact of women's labor pain experiences upon cessation of breastfeeding. We aimed to investigate the association between women's labor pain experiences, intrapartum interventions, and pre-birth psychological vulnerabilities and cessation of breastfeeding.
View Article and Find Full Text PDFCommunication skills in pediatrics: perception of medical students.
BMC Med Educ
December 2024
Graduate Program in Child and Adolescent Health, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Background: Effective communication with patients and their families is a fundamental skill for medical students to cultivate during their undergraduate training. However, communicating with pediatric patients presents unique challenges. This study investigated the perceptions, attitudes, and confidence levels of undergraduate medical students regarding communication skills in pediatrics.
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