We examined the dose-response relationship of intrathecal clonidine at small doses (
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Indirect involvement of α-adrenoceptors in the mechanical antihypersensitivity effect induced by the spinally administered imidazoline I receptor ligand LNP599 in a rat model of experimental neuropathy.
Brain Res Bull
October 2024
Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address:
Here we assess whether neuropathic pain hypersensitivity is attenuated by spinal administration of the imidazoline I-receptor agonist LNP599 and whether the attenuation involves co-activation of α-adrenoceptors. Spared nerve injury (SNI) model of neuropathy was used to induce mechanical hypersensitivity in male and female rats with a chronic catheter for intrathecal drug administrations. Mechanical sensitivity and heat nociception were assessed behaviorally in the injured limb.
View Article and Find Full Text PDFComparison of the Effect of Scalp Block With Ropivacaine vs. Ropivacaine and Clonidine on Postoperative Pain in Patients Undergoing Craniotomy Surgery Under General Anesthesia.
Cureus
August 2024
Department of Anesthesiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, IND.
Article Synopsis
- - Clonidine, an α2 agonist, improves hypotensive and analgesic outcomes when added to scalp blocks during surgery, particularly enhancing ropivacaine's effectiveness for postoperative pain management.
- - A study involved 60 ASA grade I and II patients undergoing supratentorial craniotomy, divided into two groups: one receiving ropivacaine alone and the other receiving ropivacaine with clonidine.
- - Results showed that the combination of ropivacaine and clonidine significantly prolonged analgesia duration (9.10 hours vs. 4.30 hours) and reduced tramadol consumption compared to the ropivacaine-only group, with notable differences in blood pressure readings.
Thoracic spinal anesthesia with intrathecal sedation for lower back surgery: a retrospective cohort study.
Front Med (Lausanne)
April 2024
Department of Anesthesiology and Intensive Care, St. Ivan Rilski University Hospital, Sofia, Bulgaria.
Background: Spinal anesthesia (SA) is a good alternative to general anesthesia (GA) for spine surgery. Despite that, a few case series concern the use of thoracic spinal anesthesia for short-duration surgical interventions. In search of an alternative approach to GA and a better opioid-free modality, we aimed to investigate the safety, feasibility, and patient satisfaction of thoracic SA for spine surgery.
View Article and Find Full Text PDFCatheter Tip-Associated Mass With Continuous Infusion of Sufentanil for Persistent Spinal Pain Syndrome Type 2: A Case Report Including Histopathologic Examination and Review of the Associated Basic and Clinical Research.
Neuromodulation
October 2024
Department of Anesthesiology, University of California San Diego, San Diego, CA, USA. Electronic address:
Objectives: Intrathecal opioids delivered by implanted pumps are used to treat malignant or nonmalignant chronic pain. In this study, we 1) review a case in which intrathecal infusions of sufentanil along with other adjuvants were used and after an extended period led to an intrathecal mass and 2) compared and contrasted the potential mechanisms for these phenomena.
Materials And Methods: A woman aged 66 years with a history of scoliosis and multiple spine surgeries was treated with an implantable drug delivery system for treating persistent pain after laminectomy.
Dexmedetomidine Versus Clonidine as Additives for Spinal Anesthesia: A Comparative Study.
Anesth Pain Med
August 2023
Department of Anaesthesiology, Karpaga Vinayaga Institute of Medical Sciences and Research Centre, India.
Background: Postoperative pain management is vital to improve patient care. Successful postoperative pain relief is currently achieved only through NSAIDs and narcotics.
Objectives: We compared dexmedetomidine and clonidine as additives to hyperbaric levobupivicaine 0.
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