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Prebiotics as modulators of colonic calcium and magnesium uptake.
Acta Physiol (Oxf)
February 2025
Institute for Molecular Medicine, Health and Medical University Potsdam, Potsdam, Germany.
Ca and Mg are essential nutrients, and deficiency can cause serious health problems. Thus, lack of Ca and Mg can lead to osteoporosis, with incidence rising both in absolute and age-specific terms, while Mg deficiency is associated with type II diabetes. Prevention via vitamin D or estrogen is controversial, and the bioavailability of Ca and Mg from supplements is significantly lower than that from milk products.
View Article and Find Full Text PDFThe use of Mg in investigations of the roles of intramitochondrial Ca and the mitochondrial Ca-uniporter in the stimulation of oxidative phosphorylation.
J Biol Chem
December 2024
Facultad de Ciencias - Departamento de Física - Laboratorio de Biofísica, Universidad Nacional de Colombia - Sede Medellín, Medellín, Colombia. Electronic address:
TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner.
bioRxiv
December 2024
Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Goethestr.33, 80336 Munich, Germany.
T lymphocyte activation is a crucial process in the regulation of innate and adaptive immune responses. The ion channel-kinase TRPM7 has previously been implicated in cellular Mg homeostasis, proliferation, and immune cell modulation. Here, we show that pharmacological and genetic silencing of TRPM7 leads to diminished human CD4 T-cell activation and proliferation following TCR mediated stimulation.
View Article and Find Full Text PDFThe Impacts of Volcanic Activity on Microbial Growth-A Simulation Experiment in the Qiliao Section in Shizhu County, Chongqing, China.
Biology (Basel)
November 2024
Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process, Ministry of Education, China University of Mining and Technology, Xuzhou 221008, China.
The impact of volcanic activity on microorganisms has always been a hot topic of discussion during geological history. Further studies are needed on the effects of volcanic activity on microbial growth in shale and the differences in nutrients provided by volcanic ash and other weathered rocks. This study's results indicated that TOC contents at the bottom of the shale layer are 1.
View Article and Find Full Text PDFLow-frequency rTMS Plays a Neuroprotective role in Pilocarpine-induced Status Epilepticus Rat Models Through the AMPAR GluA1-STIM-Ca Pathway.
Mol Neurobiol
October 2024
Department of Neurology, The Second Hospital of Hebei Medical University, No.215 of West Heping Road, Xinhua District, Shijiazhuang, 050000, Hebei Province, China.
Article Synopsis
- * In a study involving male Sprague-Dawley rats with induced epilepsy, low-frequency rTMS was found to significantly reduce the frequency and incidence of seizures, while also protecting hippocampal neurons from damage and death.
- * rTMS increased the expression of important proteins (AMPAR GluA1 and STIM) in the hippocampus, which may contribute to its neuroprotective effects by regulating calcium levels and reducing oxidative stress in neurons.
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