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Investigating the Relationship Between Anti-seizure Medications and Bleeding Disorders: A Comprehensive Review of the Current Literature.
Drugs Real World Outcomes
January 2025
Kabul University of Medical Sciences, Kabul, Afghanistan.
Anti-seizure medications (ASMs) are specific types of anticonvulsants used to treat epileptic seizures. However, several studies have shown an association between ASMs and an increased risk of hematological disorders, such as thrombocytopenia, aplastic anemia, and platelet function disorders leading to prolonged bleeding times. This review explores the existing literature on this topic, investigating a wide variety of ASMs, ranging from first-generation medications to newer ones.
View Article and Find Full Text PDFCommunity-based epilepsy care in an onchocerciasis-endemic area: A 3-year cohort study in Mahenge, Tanzania.
Epilepsia
December 2024
Global Health Institute, University of Antwerp, Antwerp, Belgium.
Objective: In onchocerciasis-endemic areas, limited access to antiseizure medications (ASMs) contributes to a high epilepsy burden. This study evaluated the impact of a community-based epilepsy care program in Mahenge, Tanzania, an onchocerciasis-endemic area with high epilepsy prevalence.
Methods: A baseline survey (2017-2018) identified persons with epilepsy (PWE) in four rural villages.
The association of polytherapy and psychiatric comorbidity in epilepsy.
Epilepsy Behav
December 2024
Neurosciences Unit, KEMRI Wellcome Trust Research Programme, P.O. Box 230-80108, Kilifi, Kenya; Department of Public Health, School of Human and Health Sciences, Pwani University, P.O Box 195-80108, Kilifi, Kenya; Department of Psychiatry, University of Oxford, Oxford, United Kingdom; African Population and Health Research Centre, Nairobi, Kenya. Electronic address:
Purpose: Managing epilepsy may require using more than one anti-seizure medication (ASM). While combination therapy may help, risks, including psychiatric problems, are not fully explored in Africa. We examined the relationship between polytherapy and psychiatric comorbidities among attendees of an epilepsy community clinic.
View Article and Find Full Text PDFCombined carbapenem resulted in a 4.48-fold increase in valproic acid clearance: a population pharmacokinetic model in Chinese children and adults with epilepsy or after neurosurgery.
Front Pharmacol
November 2024
Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Our study aims to explore the pharmacokinetics of valproic acid (VPA) in Chinese patients with epilepsy or after neurosurgery and establish a robust population pharmacokinetics (PPK) model. The PPK model was developed using nonlinear mixed-effects modeling, incorporating a total of 615 VPA plasma concentration data points from 443 Chinese epilepsy or after neurosurgery patients. A one-compartment model with an additive residual model was established.
View Article and Find Full Text PDFAnti-epileptic Drugs Use and Increased Risk of Stroke: A Systematic Review.
Ann Neurosci
January 2024
Maharajgunj Medical Campus, Tribhuvan University, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Antiepileptic drugs (AEDs), the predominant treatment for epilepsy, are also utilised for migraine, neuropathic pain, and bipolar disorders, accounting for 1% of usage among the common population. There is a greater risk of stroke, heart attack, and arrhythmia among AED users particularly those with enzyme-inducing properties. This systematic review aimed to look into the ischemic stroke risk among AED users, particularly in patients who had never had a cerebrovascular accident before.
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