AI Article Synopsis
- Researchers investigated cytokine expression in women with recurrent miscarriage (RM) to see if immune factors play a role in their condition.
- The study involved three groups: women with RM after multiple miscarriages, women who had miscarried but were now past the critical period, and women with no history of miscarriage, with specific attention given to cytokine levels like IL-2 and IL-10.
- Results showed higher levels of IL-2 in women with RM and highlighted that IL-10 is crucial for maintaining a healthy pregnancy.
Article Abstract
It has been postulated that a proportion of recurrent miscarriage (RM) might be due to immune causes. The objective was to determine whether cytokine expression in peripheral blood mononuclear cell is altered in patients with a history of RM. We compared the levels of IL-2, IL-4, IL-10, IL-13, TGFbeta1 and IFNgamma in the supernatant of Phytohemagglutinin stimulated mononuclear cells in 21 women with RM at the time of 3rd or higher abortion (group I), 32 women who were at least 3 months past their 3rd or higher abortion (group II) and 32 pregnant women with no history of abortion (group III). Gestational age was matched between groups I and III. Group I had higher level of IL-2 than group III (P=0.001). Group II showed higher level of IL-2 (P=0.001) and IFNgamma (P=0.015) than group III. The production of IL-10 by mononuclear cells of group III was higher than both group I (P=0.002) and group II (P=0.001). There was no difference in the levels of IL-2, IL-10 and IFNgamma between groups I and II. Also, the levels of IL-4, IL-13, and TGFbeta1 were similar among the groups. The data indicate an elevation of Th1 cytokines in women with RM as compared to normal pregnant women, and IL-10 is an important cytokine in the maintenance of pregnancy.
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| http://dx.doi.org/10.1016/j.cyto.2004.07.002 | DOI Listing |
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