Background: Inflammatory processes are an integral component of the initiation, progression, and destabilization of atherosclerotic lesions. Tumor necrosis factor-alpha (TNF-alpha) is considered a primary mediator of inflammatory processes.

Methods And Results: The role of TNF-alpha in plaque progression and plaque destabilization was investigated in the innominate arteries of older TNF-alpha receptor p55 deficient mice that were generated on a hyperlipidemic apolipoprotein E deficient background (p55-/- apoE-/-). There were no significant differences in levels of circulating cytokines, plaque progression, plaque composition or features of plaque destabilization in p55-/- apoE-/- compared to wild type (p55+/+ apoE-/-) mice.

Conclusions: Progression and destabilization of advanced atherosclerotic lesions does not seem to be mediated via the TNF-alpha receptor p55.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2004.05.033DOI Listing

Publication Analysis

Top Keywords

progression plaque
12
receptor p55
12
plaque composition
8
tumor necrosis
8
necrosis factor-alpha
8
progression destabilization
8
atherosclerotic lesions
8
plaque progression
8
plaque destabilization
8
tnf-alpha receptor
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!