To explore the distinct background of bone marrow and embryonic yolk sac hematopoiesis performance, serum free murine yolk sac endothelial cell and bone marrow endothelial cell conditioned medium were compared for their effects on the development profiles of yolk sac hematopoietic stem/progenitor cells. The mRNAs expression techniques were applied to understand the cytokine and receptor genes expression and the possible mechanisms. The results suggested that the differential gene expressions were existed between the hematopoietic cells of yolk sac and bone marrow and between the microenvironment of yolk sac and bone marrow.
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| http://dx.doi.org/10.1016/j.leukres.2004.03.006 | DOI Listing |
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