AI Article Synopsis
- 5-Carboxamido-1,3,2-dioxaphosphorinanes are effective inhibitors of microsomal triglyceride-transfer protein, which plays a role in lipid metabolism.
- The unique 1,3,2-dioxaphosphorine structure serves as a stable and neutral alternative to existing compounds like piperidine and piperidine N-oxide.
- This discovery may contribute to the development of new therapeutic strategies targeting lipid-related diseases.
Article Abstract
5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.
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| http://dx.doi.org/10.1016/j.bmcl.2004.07.069 | DOI Listing |
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