Protein degradation: recognition of ubiquitinylated substrates.

Curr Biol

August Krogh Institute, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.

Published: September 2004

A cell-free system has been developed in budding yeast that provides direct evidence that the Dsk2/Dph1, Rad23/Rhp23 and Rpn10/Pus1 multi-ubiquitin-binding proteins, long implicated in substrate recognition and presentation to the 26S proteasome, actually fulfil such a role.

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http://dx.doi.org/10.1016/j.cub.2004.09.012DOI Listing

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