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Risk Stratification of Uterine Smooth Muscle Tumors: The Role of Morphology, Immunohistochemistry, and Molecular Testing.
Adv Anat Pathol
January 2025
Department of Pathology, University of Michigan-Michigan Medicine, Ann Arbor, MI.
Uterine smooth muscle neoplasms are a biologically and clinically heterogeneous group of tumors. Morphology is the cornerstone of pathologic diagnosis of these tumors, and most are readily classified as benign or malignant on the basis of routine histologic examination. However, rare subsets-including intravenous leiomyomatosis, benign metastasizing leiomyoma, and disseminated peritoneal leiomyomatosis-have a capacity for extrauterine spread despite benign cytomorphology.
View Article and Find Full Text PDFVaginal lacerations during laparoscopic hysterectomy for endometrial cancer and local recurrence risk.
Gynecol Oncol Rep
August 2024
Hanjani Institute for Gynecologic Oncology, Asplundh Cancer Pavilion of Sidney Kimmel Cancer Center, Thomas Jefferson University, 3941 Commerce Avenue, Willow Grove, PA 19090, United States.
Objective: Laparoscopic surgery (MIS) offers equivalent oncologic outcomes as compared to open surgery, while causing lesser morbidity and resulting in a faster recovery. Vaginal extraction of specimens may cause vaginal or perineal lacerations (VL). The objective of this retrospective study was to assess local recurrence rates compared between cases with vaginal laceration (VL) or without vaginal lacerations (NL).
View Article and Find Full Text PDFCurrent management of familial adenomatous polyposis.
Expert Rev Anticancer Ther
June 2024
Hereditary Digestive Tract Tumors Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Article Synopsis
- APC-associated polyposis is a rare genetic condition causing multiple adenomas in the digestive system, requiring care from specialized multidisciplinary teams.
- The study reviews Familial adenomatous polyposis (FAP) management, highlighting the importance of personalized approaches that include diagnosis, surveillance, preventive surgery, and attention to extracolonic tumors.
- Expert opinion emphasizes a comprehensive management strategy utilizing genetic insights and new monitoring methods to enhance outcomes and quality of life for individuals with FAP.
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- * Data from 4,088 lesions were analyzed, revealing that PRA was used in 19.2% of cases, with high success rates for both guidewire (93.6%) and technical procedures (91.3%).
- * Key characteristics linked to the use of PRA included previous coronary artery bypass surgery, chronic kidney disease, and specific lesion features like blunt stumps and distal runoff under 1 mm, providing insights for choosing PCI strategies in clinical practice.
EDST: a decision stump based ensemble algorithm for synergistic drug combination prediction.
BMC Bioinformatics
August 2023
Institute of Health Service and Transfusion Medicine, Beijing, China.
Introduction: There are countless possibilities for drug combinations, which makes it expensive and time-consuming to rely solely on clinical trials to determine the effects of each possible drug combination. In order to screen out the most effective drug combinations more quickly, scholars began to apply machine learning to drug combination prediction. However, most of them are of low interpretability.
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