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Early Versus Late Atrial Fibrillation Recurrence After Pulsed Field Ablation: Insights From the admIRE Trial.
Europace
January 2025
Texas Cardiac Arrhythmia Research Foundation, Austin, TX, USA.
Background And Aims: Studies have shown correlations between early recurrence (ER) and late recurrence (LR) of atrial arrhythmia after ablation with thermal technologies. This admIRE trial (NCT05293639) subanalysis aims to analyze ER versus LR in patients with paroxysmal atrial fibrillation (PAF) undergoing pulsed field ablation (PFA).
Methods: Patients with symptomatic paroxysmal atrial fibrillation and ≥1 transtelephonic monitoring transmission during the blanking period were included (n=169).
Acid sphingomyelinase deficiency and Gaucher disease: Underdiagnosed and often treatable causes of hepatomegaly, splenomegaly, and low HDL cholesterol in lean individuals.
Hepatol Commun
January 2025
Research and Development, Sanofi, Cambridge, Massachusetts, USA.
Background: Acid sphingomyelinase deficiency (ASMD) and Gaucher disease type 1 (GD1) are rare inherited sphingolipid disorders with multisystemic manifestations, including liver disease and dyslipidemia. Despite effective treatments, insufficient disease awareness frequently results in diagnostic delays during which irreversible complications occur. We delineated the shared and distinctive features of hepatic, splenic, and lipoprotein phenotypes in ASMD and GD1.
View Article and Find Full Text PDFEffects of the Quantum Vacuum at a Cosmic Scale and of Dark Energy.
Entropy (Basel)
November 2024
Departamento de Física, Universidad de Cantabria, 39005 Santander, Spain.
The Einstein equation in a semiclassical approximation is applied to a spherical region of the universe, with the stress-energy tensor consisting of the mass density and pressure of the ΛCDM cosmological model plus an additional contribution due to the quantum vacuum. Expanding the equation in powers of Newton constant G, the vacuum contributes to second order. The result is that at least a part of the acceleration in the expansion of the universe may be due to the quantum vacuum fluctuations.
View Article and Find Full Text PDFFostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.
JAMA Netw Open
December 2024
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Importance: Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19.
Objective: To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia.
Design, Setting, And Participants: This multicenter, phase 3, placebo-controlled, double-blinded randomized clinical trial was conducted at 41 US sites and 21 international sites between November 17, 2021, and September 27, 2023; the last follow-up visit was December 31, 2023.
Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design.
Eur Child Adolesc Psychiatry
December 2024
Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Article Synopsis
- * Researchers analyzed data from 2,511 children and adolescents in Brazil, comparing ADHD biomarkers like polygenic scores, subcortical volumes, and executive function among different risk groups.
- * Findings showed that a risk-informed approach significantly highlighted differences in biomarkers, suggesting this method could improve evaluations for ADHD and potentially other mental disorders.
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