AI Article Synopsis
- PKMzeta is an important protein kinase involved in memory formation and long-term potentiation in the brain.
- Its mRNA is specifically transported and localized to dendritic regions of neurons, aided by two key elements that direct its movement within the cell.
- The presence of translational control mechanisms near PKMzeta mRNA in dendrites suggests it plays a role in integrating synaptic signaling with local protein synthesis.
Article Abstract
Protein kinase Mzeta (PKMzeta) is an atypical protein kinase C isoform that has been implicated in the protein synthesis-dependent maintenance of long term potentiation and memory storage in the brain. Synapse-associated kinases are uniquely positioned to promote enduring consolidation of structural and functional modifications at the synapse, provided that kinase mRNA is available on site for local input-specific translation. We now report that the mRNA encoding PKMzeta is rapidly transported and specifically localized to synaptodendritic neuronal domains. Transport of PKMzeta mRNA is specified by two cis-acting dendritic targeting elements (Mzeta DTEs). Mzeta DTE1, located at the interface of the 5'-untranslated region and the open reading frame, directs somato-dendritic export of the mRNA. Mzeta DTE2, in contrast, is located in the 3'-untranslated region and is required for delivery of the mRNA to distal dendritic segments. Colocalization with translational repressor BC1 RNA in hippocampal dendrites suggests that PKMzeta mRNA may be subject to translational control in local domains. Dendritic localization of PKMzeta mRNA provides a molecular basis for the functional integration of synaptic signal transduction and translational control pathways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828843 | PMC |
| http://dx.doi.org/10.1074/jbc.M409240200 | DOI Listing |
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