This study examined the effects of streptozotocin (STZ)-diabetes and dietary long chain polyunsaturated fatty acids (LC-PUFAs) on hippocampal N-methyl-D-aspartate (NMDA) receptor subunit expression and lipid peroxidation. MDA level was significantly increased after 8 weeks of STZ-diabetes. LC-PUFAs administration significantly reduced MDA levels in diabetic rats. NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats. Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats. Consequently, dietary LC-PUFAs can partially restore hippocampal NMDA receptors and decrease lipid peroxidation in diabetes. LC-PUFAs are thus a possible prophylactic means for preventing the cognitive deficiencies of diabetes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/00207450490476147 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Amalgamation of Metal Tolerant PGPR sp. EA20 with Birch Wood Biochar Enhanced Growth and Biofortification of Rapeseed under Copper Action.
Front Biosci (Elite Ed)
November 2024
Department of Life Sciences, GITAM School of Science, Gandhi Institute of Technology and Management, 530045 Visakhapatnam, Andhra Pradesh, India.
Background: Amalgamation of metal-tolerant plant growth promoting rhizobacteria (PGPR) with biochar is a promising direction for the development of chemical-free biofertilizers that can mitigate environmental risks, enhance crop productivity and their biological value. The main objective of the work includes the evaluation of the influence of prepared bacterial biofertilizer (BF) on biometric growth parameters as well as physiological and biochemical characteristics of rapeseed ( L.) at copper action.
View Article and Find Full Text PDFBerberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice.
Exp Biol Med (Maywood)
December 2024
Institute of Disease-Oriented Nutritional Research, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Advanced glycation end products (AGEs) have adverse effects on the development of diabetic complications. Berberine (BBR), a natural alkaloid, has demonstrated its ability to promote the delayed healing of skin wounds. However, the impact of BBR on AGEs-induced ferroptosis in skin cells and the underlying molecular mechanisms remains unexplored.
View Article and Find Full Text PDFMechanism and application prospect of ferroptosis inhibitors in improving osteoporosis.
Front Endocrinol (Lausanne)
December 2024
Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Osteoporosis, a prevalent bone metabolic disorder, has emerged as a pressing global public health concern. Recent studies have illuminated a crucial link between ferroptosis and the pathogenesis of osteoporosis. Nevertheless, the intricate mechanisms underlying the role of ferroptosis in this condition remain largely unexplored.
View Article and Find Full Text PDFIdentification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.
Front Immunol
December 2024
School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Background: Thyroid-associated orbitopathy (TAO) is an autoimmune inflammatory disorder of the orbital adipose tissue, primarily causing oxidative stress injury and tissue remodeling in the orbital connective tissue. Ferroptosis is a form of programmed cell death driven by the accumulation of reactive oxygen species (ROS), iron metabolism disorder, and lipid peroxidation. This study aims to identify and validate the optimal feature genes (OFGs) of ferroptosis with diagnostic and therapeutic potential in TAO orbital adipose tissue through bioinformatics analysis and to assess their correlation with disease-related immune cell infiltration.
View Article and Find Full Text PDFInvestigating the effects of co-exposure to noise and benzene on serum oxidative stress in rat.
Toxicol Rep
December 2024
Department of Occupational Health and Ergonomic, Qazvin Medical University, Qazvin, Iran.
Occupational exposures are generally complex, workers are exposed with more than one hazardous agent in work environment. Combined exposure to noise and benzene is common in occupational environments. Sub-acute exposure to benzene vapors can induce oxidative stress in serum.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!