Two polymorphs of trans-13-azabicyclo[10.2.0]tetradecan-14-one display a unique example of isostructurality, differing only in the orientation of a given hydrogen bond with respect to the beta-lactam bond. This slight difference can be attributed to the twofold rotation of the carbocyclic macroring of C2 symmetry, which in the crystal structure is hardly noticeable.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/b408505a | DOI Listing |
Front Cell Infect Microbiol
December 2024
Department of Infection Control, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Systemic inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR) can effectively predict the prognosis of various inflammatory diseases. However, its prognostic effect on patients with carbapenem-resistant (CRKP) infection is little known. The objective of this study was to investigate the risk factors for mortality associated with CRKP infection and the clinical value of NLR in predicting prognosis in these patients.
View Article and Find Full Text PDFEur J Pediatr
November 2024
Pediatric Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Front Microbiol
October 2024
Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Background: Airway mucus hypersecretion (AMH) can occur in children with acute respiratory diseases, but its underlying mechanisms and relationship with the lower respiratory tract microbiota (LRTM) are not yet fully understood. This study investigates the characteristics of LRTM in children with pneumonia (MPP) and its impact on AMH.
Methods: We collected bronchoalveolar lavage fluid and related clinical indicators from 202 children with MPP.
Front Cell Infect Microbiol
September 2024
Department of Infectious Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Objectives: To summarize the clinical characteristics, outcomes and identify risk factors of (AB) meningitis in children.
Methods: This was a single-center, retrospective study. Children hospitalized between January 2016 and December 2021 who were diagnosed with AB meningitis were included.
Sci Adv
September 2024
Section of Microbiology and Immunology, Division of Biology, Kansas State University, Manhattan, KS 66506, USA.
Carbapenem-resistant (CRKP) causes Gram-negative lung infections and fatal pneumonic sepsis for which limited therapeutic options are available. The lungs are densely innervated by nociceptor sensory neurons that mediate breathing, cough, and bronchoconstriction. The role of nociceptors in defense against Gram-negative lung pathogens is unknown.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!