The degenerate Y chromosome--can conversion save it?

Reprod Fertil Dev

Research School of Biological Sciences, The Australian National University, Canberra, ACT, Australia.

Published: October 2007

The human Y chromosome is running out of time. In the last 300 million years, it has lost 1393 of its original 1438 genes, and at this rate it will lose the last 45 in a mere 10 million years. But there has been a proposal that perhaps rescue is at hand in the form of recently discovered gene conversion within palindromes. However, I argue here that although conversion will increase the frequency of variation of the Y (particularly amplification) between Y chromosomes in a population, it will not lead to a drive towards a more functional Y. The forces of evolution have made the Y a genetically isolated, non-recombining entity, vulnerable to genetic drift and selection for favourable new variants sharing the Y with damaging mutations. Perhaps it will even speed up the decline of the Y chromosome and the onset of a new round of sex-chromosome differentiation. The struggle to preserve males may perhaps lead to hominid speciation.

Download full-text PDF

Source
http://dx.doi.org/10.10371/RD03096DOI Listing

Publication Analysis

Top Keywords

degenerate chromosome--can
4
chromosome--can conversion
4
conversion save
4
save it?
4
it? human
4
human chromosome
4
chromosome running
4
running time
4
time 300
4
300 years
4

Similar Publications

The degenerate Y chromosome--can conversion save it?

Reprod Fertil Dev

October 2007

Research School of Biological Sciences, The Australian National University, Canberra, ACT, Australia.

The human Y chromosome is running out of time. In the last 300 million years, it has lost 1393 of its original 1438 genes, and at this rate it will lose the last 45 in a mere 10 million years. But there has been a proposal that perhaps rescue is at hand in the form of recently discovered gene conversion within palindromes.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!