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Phage vB_KlebPS_265 Active Against Resistant/MDR and Hypermucoid K2 Strains of .
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Laboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
is an important opportunistic pathogen often resistant to antibiotics. Specific phages can be useful in eliminating infection caused by . phage vB_KlebPS_265 (KlebP_265) and its host strain were isolated from the sputum of a patient with infection.
View Article and Find Full Text PDF()-Glucosciadopitysin, a New Biflavonoid Glycoside from the Leaves of and Osteogenic Activity of Bioflavonoids.
Plants (Basel)
January 2025
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
The leaves of have been used in treating freckles and effectively reducing cough and sputum in folk medicines. Recently, investigations into the correlation between ginkgo leaves and the proliferative activity of osteogenic differentiation have been conducted. However, bioactive compounds that enhance osteogenesis or exhibit osteoporosis prevention from have not been fully identified.
View Article and Find Full Text PDFGene Expression Profiles Reveal Distinct Mechanisms Driving Chronic Obstructive Pulmonary Disease Exacerbations.
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January 2025
Hospital General Universitario de Elche-FISABIO, 03203 Elche, Spain.
Chronic obstructive pulmonary disease (COPD) exacerbations are major contributors to morbidity and mortality, highlighting the need to better understand their molecular mechanisms to improve prevention, diagnosis, and treatment. This study investigated differential gene expression profiles and key biological processes in COPD exacerbations categorized based on sputum microbiome profiling. An observational study was performed on a cohort of 16 COPD patients, who provided blood and sputum samples during exacerbations, along with five stable-state samples as controls.
View Article and Find Full Text PDFTherapeutic rigid bronchoscopy for endobronchial glomus tumors: a case series.
BMC Pulm Med
January 2025
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Background: Glomus tumors (GTs) are rare, comprising only 2% of all soft tissue tumors. Pulmonary GTs are exceptionally rare, with fewer than 80 cases reported to date. Little is known about the therapeutic outcomes of rigid bronchoscopy for endobronchial GT.
View Article and Find Full Text PDFPositive sputum fungal culture, fungal sensitisation and airway microbial diversity in asthmatic children.
Med Mycol
January 2025
Department of Respiratory Sciences, College of Life Sciences, NIHR Biomedical Research Centre (Respiratory theme), University of Leicester, Leicester, UK. Department of Paediatric Respiratory Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.
Sensitisation to thermotolerant fungi such as Aspergillus fumigatus and Candida albicans which can colonise the airways is associated with poor lung function in children with asthma. Dysbiosis of bacteria and fungi in the airway microbiome has been reported between health and asthma but has yet to be characterised for fungal sensitised asthmatic children. We investigated if microbial diversity of the airways is altered in fungal sensitised school-age asthmatic children.
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