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Genetic testing in early-onset atrial fibrillation.
Eur Heart J
September 2024
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, 415 Main St, 02412, Cambridge, MA, USA.
Article Synopsis
- * The 2023 ACC/AHA guidelines recommend genetic testing for AF patients aged 45 or younger to enhance personalized care and prognosis by identifying specific genetic defects.
- * Challenges in genetic testing for AF include interpreting uncertain results, financial and insurance barriers, and the need for improved training and standardization in testing procedures.
LINE-1 retrotransposons contribute to mouse PV interneuron development.
Nat Neurosci
July 2024
Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Retrotransposons are mobile DNA sequences duplicated via transcription and reverse transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons can also promote the transcription of adjacent genes. Somatic LINE-1 (L1) retrotransposon insertions have been detected in mammalian neurons.
View Article and Find Full Text PDFAn international multicenter cohort study on implantable cardioverter-defibrillators for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia.
Heart Rhythm
October 2024
BC Children's Hospital, Division of Cardiology, Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) may cause sudden cardiac death (SCD) despite medical therapy. Therefore, implantable cardioverter-defibrillators (ICDs) are commonly advised. However, there is limited data on the outcomes of ICD use in children.
View Article and Find Full Text PDFA pioneer Turkish urologist-medical historian (Saim Erkun 1901-1949) and his one-century-old review about prostate.
J Med Biogr
November 2024
Department of Urology, Medistate Hospital, Istanbul, Turkey.
Article Synopsis
- The text discusses the life and career of a pioneering urologist from the late Ottoman and early Turkish Republic eras, highlighting his contributions to medicine from 1901 to 1949.
- He received a strong medical education and was among the first urology residents in Turkey, performing various procedures and documenting his findings with a blend of traditional Ottoman knowledge and modern scientific methods.
- The manuscript emphasizes the significance of his work on the prostate in urology, illustrating how the field evolved in Turkey post-World War I through the efforts of dedicated young clinicians during the transition from the Ottoman Empire to the modern Turkish state.
Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction.
JACC Basic Transl Sci
December 2023
Department of Internal Medicine and University Heart Center, Division of Cardiology, Medical University of Graz, Graz, Austria.
Irreversible fibrosis is a hallmark of myocardial infarction (MI) and heart failure. Extracellular matrix protein-1 (ECM-1) is up-regulated in these hearts, localized to fibrotic, inflammatory, and perivascular areas. ECM-1 originates predominantly from fibroblasts, macrophages, and pericytes/vascular cells in uninjured human and mouse hearts, and from M1 and M2 macrophages and myofibroblasts after MI.
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