AI Article Synopsis
- Preeclampsia's underlying causes are still not fully understood, but certain factors from the placenta seem to contribute to the condition's symptoms and complications.
- A study measured serum levels of sFlt-1, a placenta-produced factor, in 11 women with preeclampsia and 11 healthy controls using the ELISA method.
- Results showed that women with preeclampsia had sFlt-1 levels that were twice as high as those in healthy pregnant women, with the highest levels found in severe cases, suggesting that sFlt-1 could serve as a useful diagnostic marker for preeclampsia.
Article Abstract
Unlabelled: The pathophysiology of preeclampsia remains largely unknown. A number of circulating placenta-produced factors have been implicated in causing the endothelial dysfunction and the clinical phenotype characteristic of preeclampsia.
Aim: Determination of serum levels of placental soluble fms-like tyrosine-kinase-1 (sFlt-1) in pregnant women with preeclampsia. Eleven pregnant women with preeclampsia and 11 healthy women (controls) were included in the study. Determination of sFlt-1 was done with ELISA. The mean serum sFlt-1 levels of pregnant women with preeclampsia were twice as high as that of women with normal pregnancy. The highest level of sFlt-1 was found in women with severe preeclampsia. In women with mild form of preeclampsia the sFlt-1 level was close to that of the controls. sFlt-1 appears to be involved in the pathogenesis of preeclampsia and its serum levels can be used as a diagnostic marker of preeclampsia.
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