AI Article Synopsis
- Acute bacterial rhinosinusitis (ABRS) typically develops after a viral infection or allergy, with symptoms worsening after 5-7 days or not improving after 10 days.
- Streptococcus pneumoniae and Haemophilus influenzae are common bacterial culprits, but rising antibiotic resistance complicates treatment.
- A new formulation of amoxicillin-clavulanate has been created to effectively address these resistant strains, offering a higher daily dose and improved coverage against resistant pathogens.
Article Abstract
Acute bacterial rhinosinusitis (ABRS) is a secondary bacterial infection of the nose and paranasal sinuses, usually preceded by a viral upper respiratory infection or allergy, with symptoms that have not improved after 10 days or that have worsened after 5 to 7 days. Streptococcus pneumoniae and Haemophilus influenzae are the most common causes of ABRS in adults. Increasing rates of antimicrobial resistance among S. pneumoniae and beta-lactamase production among H. influenzae are formidable challenges to the successful treatment of infections caused by these organisms. To this end, various formulations of amoxicillin-clavulanate have been developed, the most recent of which is pharmacokinetically enhanced and provides a total daily dose of 4,000 mg of amoxicillin and 250 mg of clavulanate. This formulation has been shown to be safe and effective in the treatment of infections caused by penicillin-resistant S. pneumoniae (minimum inhibitory concentration 2 microg/mL); the clavulanate component provides adequate coverage of beta-lactamase-producing pathogens.
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| http://dx.doi.org/10.1016/j.amjmed.2004.07.005 | DOI Listing |
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