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Deferred cytoreductive nephrectomy in patients with metastatic renal cell carcinoma: A systematic review and patient-level meta-analysis.
Urol Oncol
January 2025
Department of Urology, Singapore General Hospital, Singapore; SingHealth Duke-NUS Transplant Centre, Singapore. Electronic address:
There has been much controversy regarding the order in which cytoreductive nephrectomy (CN) and systemic therapy (ST) are applied for patients with metastatic renal cell carcinoma (mRCC). We aimed to investigate the role of deferred CN (dCN) in mRCC, particularly in the current era of immunotherapy. A systematic literature search was conducted on PubMed, Embase, and Scopus for studies comparing dCN versus any non-dCN strategy, in any temporal sequence, with the provision of Kaplan-Meier curves for overall survival (OS).
View Article and Find Full Text PDFSeparating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study.
J Obes Metab Syndr
January 2025
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Whether there is a causal relationship between childhood obesity and increased risk of chronic kidney disease (CKD) remains controversial. This study sought to explore how body size in childhood and adulthood independently affects CKD risk in later life using a Mendelian randomization (MR) approach.
Methods: Univariate and multivariate MR was used to estimate total and independent effects of body size exposures.
Effect of prebiotic supplementation on health status in adults with prediabetes: a systematic review and meta-analysis of randomized clinical trials.
J Nutr
January 2025
Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
Prediabetes with a considerable progression rate is a primary risk factor for type 2 diabetes, if left untreated. Dietary interventions examining the health effects of prebiotic consumption on health status have been studied in subjects with prediabetes but the results are controversial. This study aimed to investigate whether prebiotic consumption can favorably alter metabolic status as well as anthropometric features in subjects with prediabetes.
View Article and Find Full Text PDFThe lesser tuberosity C-block osteotomy for anatomical total shoulder arthroplasty has no negative impact on the volumetric ratio of the transversal force couple.
J Shoulder Elbow Surg
January 2025
Department of Orthopaedic Surgery and Traumatology, UZ Gent, C. Heymanslaan 10, 9000 Gent, Belgium.
Background: Mobilization of the subscapularis muscle (SSC) is crucial for optimal access to the glenohumeral joint during anatomical total shoulder arthroplasty (ATSA). However, the ideal mobilization technique remains controversial. This study aimed to assess the impact of the lesser tuberosity C-block osteotomy, a modified lesser tuberosity osteotomy, on the postoperative subscapularis (SSC) volume following anatomical shoulder arthroplasty and compare it to the volume of the infraspinatus/teres minor.
View Article and Find Full Text PDFCFTR mutation is associated with bone differentiation abnormalities in cystic fibrosis.
J Cyst Fibros
January 2025
The Lundquist Institute, Harbor-UCLA Medical Center, Torrance 90502 CA, USA. Electronic address:
Background: Cystic Fibrosis-related Bone Disease is an emerging challenge faced by 50 % of adult people with cystic fibrosis (CF). The multifactorial causes of this comorbidity remain elusive. However, congenital bone defects have been observed in animal models with CFTR mutations, suggesting its importance.
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