AI Article Synopsis
- Mortality from ischemic cardiovascular diseases is higher in the elderly compared to young adults, with the study hypothesizing that this increased vulnerability is due to decreased antioxidative capacity in aged hearts after ischemia-reperfusion (MI/R) injury.
- Experiments with young (4-month-old) and aged (20-month-old) rats showed that young rats had greater signs of oxidative stress and inflammation after MI/R, indicated by higher leukocyte infiltration and myeloperoxidase activity.
- In contrast, aged rats displayed more severe reperfusion damage linked to lower antioxidative capacity, as shown by a decreased glutathione ratio, suggesting that aging affects the heart’s response to oxidative stress during reperfusion.
Article Abstract
Mortality due to ischemic cardiovascular diseases is significantly higher in elderly than in young adults. Myocardial ischemia-reperfusion (MI/R) can induce oxidative stress and an inflammatory response. We hypothesized that increased vulnerability of aged myocardium to reperfusion injury could be caused by decreased antioxidative capacity, rather than increased oxidant production, after MI/R. Aged (20-mo-old) and young (4-mo-old) male F344BN rats were subjected to 30 min of myocardial ischemia by ligation of the left main coronary artery followed by release of the ligature and 4 h of reperfusion. Four experimental groups were studied: young sham-operated rats, aged sham-operated rats, young rats subjected to MI/R, and aged rats subjected to MI/R. MI/R significantly increased infiltrated leukocyte number and myeloperoxidase (MPO) activity in perinecrotic areas of hearts of young rats compared with aged MI/R rats. These changes in infiltrated leukocyte number and MPO activity were associated with an increase in superoxide generation in perinecrotic areas from hearts of young rats compared with aged rats. Plasma levels of TNF-alpha and IL-1beta were significantly higher in young than in aged MI/R rats. However, plasma 8-hydroxy-2'-deoxyguanosine levels and creatine kinase activity were increased in aged compared with young MI/R rats. Increased reperfusion damage in aged rats was associated with a significant decrease in plasma ratio of GSH to GSSG. Our results suggest that enhanced ischemia-reperfusion injury in aged rat hearts may be related to reduced antioxidative capacity, rather than increased reactive oxygen species production. These findings contribute to a better understanding of effects of aging on oxidative stress and inflammatory responses of the heart after MI/R.
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| http://dx.doi.org/10.1152/ajpheart.00317.2004 | DOI Listing |
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