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Therapeutic Approaches for Advanced Basal Cell Carcinoma: A Comprehensive Review.
Cancers (Basel)
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Department of Dermatology and Allergology, Paracelsus Medical University, Muellner Hauptstraße 48, 5020 Salzburg, Austria.
Basal cell carcinoma (BCC) accounts for 80% of skin cancer cases. Although mostly curable by simple excision, the treatment of advanced disease can be challenging, as curative surgery or radiotherapy may not always be feasible. The scope of this review is to summarize current knowledge on molecular mechanisms in BCC pathogenesis, to elaborate on the definition of advanced/difficult-to-treat BCC, and to outline systemic treatment options.
View Article and Find Full Text PDFComparative Study on Combined Addition of Gd-Ce and Gd-Y on the Mechanical Properties and Electrochemical Behavior of Mg-Zn-Mn-Ca Alloys.
Materials (Basel)
January 2025
School of Materials Science and Engineering, Guangdong Ocean University (Yangjiang Campus), Yangjiang 529500, China.
This study presents a comparative analysis of the influence of Ce-Gd and Gd-Y additions on the microstructural evolution, mechanical properties, and electrochemical behavior of extruded Mg-3Zn-Mn-Ca alloy rods. Despite the frequent incorporation of Gd, Y, and Ce as alloying elements in magnesium alloys, the systematic examination of their combined effects on Mg-Zn alloys has been limited. Our findings reveal that both Gd-Ce and Gd-Y additions significantly enhance the mechanical properties of Mg-3Zn-Mn-Ca alloy, although through differing mechanisms.
View Article and Find Full Text PDFStudy on Influence of Mechanical Behavior of AZ31 Magnesium Alloy Based on GTN Damage Modeling.
Materials (Basel)
December 2024
School of Materials Science and Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China.
Damage mechanisms are a key factor in materials science and are essential for understanding and predicting the behavior of materials under complex loading conditions. In this paper, the influence of different directions, different rates and different model parameters on the mechanical behavior of AZ31 magnesium alloy during the tensile process is investigated based on the secondary development of the VUMAT user subroutine based on the GTN damage model and verified by the tensile experiments at different loading rates and in different directions. The results show that AZ31 magnesium alloy exhibits significant differences in mechanical properties in radial and axial stretching, where the yield strength is lower in the radial direction than in the axial direction, and the elongation is the opposite.
View Article and Find Full Text PDFIntegrated Analysis of Cell-Free DNA and Novel Protein Biomarkers for Stratification and Therapy Monitoring in Stage IV Pancreatic Cancer: A Preliminary Study.
Diagnostics (Basel)
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Department of Medicine I (Hematology, Oncology and Stem Cell Transplantation), Freiburg University Medical Center, 79106 Freiburg, Germany.
Given the poor prognosis of metastatic pancreatic adenocarcinoma (mPDAC), closer disease monitoring through liquid biopsy, most frequently based on serial measurements of cell-free mutated ( cfDNA), has become a highly active research focus, aimed at improving patients' long-term outcomes. However, most of the available data show only a limited predictive and prognostic value of single-parameter-based methods. We hypothesized that a combined longitudinal analysis of cfDNA and novel protein biomarkers could improve risk stratification and molecular monitoring of patients with mPDAC.
View Article and Find Full Text PDFCombining Controlled-Release and Normal Urea Enhances Rice Grain Quality and Starch Properties by Improving Carbohydrate Supply and Grain Filling.
Plants (Basel)
January 2025
Jiangsu Key Laboratory of Crop Genetics and Physiology, Jiangsu Key Laboratory of Crop Cultivation and Physiology, Agricultural College, Yangzhou University, Yangzhou 225009, China.
Controlled-release nitrogen fertilizers are gaining popularity in rice ( L.) cultivation for their ability to increase yields while reducing environmental impact. Grain filling is essential for both the yield and quality of rice.
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