During the late eighteenth and early nineteenth centuries the Hudson's Bay Company served as a de facto public health agency across western Canada. Among its biggest challenges was combating the smallpox epidemics that periodically threatened the Aboriginal people of the region. Initially, the Company's employees turned to quarantine over variolation in order to prevent the spread of the disease to Hudson Bay in the summer of 1782. Although well thought-out, ultimately this policy proved unsuccessful. Within thirty years the HBC had turned to the newly discovered vaccination, a strategy that was to prove far more effective in fighting the disease. By the late 1830s the Company was able to mount an effective vaccination campaign that covered much of western Canada.
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http://dx.doi.org/10.1353/bhm.2004.0119 | DOI Listing |
Curr Rheumatol Rep
December 2024
Department of Medicine, Division of Rheumatology, Queen's University, Kingston, ON, Canada.
Purpose Of Review: The canonical pathogenesis of spondyloarthritis (SpA) involves inflammation driven by HLA-B27, type 3 immunity, and gut microbial dysregulation. This review based on information presented at the SPARTAN meeting highlights studies on the pathogenesis of SpA from the past year, focusing on emerging mechanisms such as the roles of microbe-derived metabolites, microRNAs (miRNAs) and cytokines in plasma exosomes, specific T cell subsets, and neutrophils.
Recent Findings: The induction of arthritis in a preclinical model through microbiota-driven alterations in tryptophan catabolism provides new insights as to how intestinal dysbiosis may activate disease via the gut-joint axis.
Res Involv Engagem
December 2024
Rotman Research Institute, Baycrest Academy for Research and Education, 3560 Bathurst Street, Toronto, ON, M6A 2E1, Canada.
Background: Collaborative research with end-users is an effective way to generate meaningful research applications and support greater impact on practice and knowledge exchange. To address these needs, a Citizen Advisory Group (CAG) of nine older adults (ages 64-80, 67% women) was formed to advise scientists on the development of Brain Health PRO (BHPro), a web-based platform designed to increase dementia prevention literacy and awareness. The current study evaluated if the CAG met its objectives, how inclusion of the CAG aligned with collaborative research approaches, and the CAG's experience and satisfaction throughout the development process.
View Article and Find Full Text PDFClin Biochem
December 2024
Department of Pathology and Laboratory Medicine, London Health Sciences Centre and St. Joseph's Health Care London, London, ON, Canada; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Background: Mass spectrometry methods are emerging as tools to detect M-proteins in the serum of multiple myeloma patients with increased sensitivity and specificity compared to traditional electrophoretic methods.
Methods: A liquid handling system, the Agilent AssayMAP Bravo, with liquid chromatography high-resolution quadrupole-time-of-flight (LC-QTOF) mass spectrometry to analyze intact light chains was compared to immunofixation electrophoresis (IFE) for M-protein analysis. 210 patient serum samples were analyzed in a split sample comparison (LC-QTOF vs.
J Plast Reconstr Aesthet Surg
November 2024
McMaster University, Department of Surgery, Division of Plastic Surgery, Hamilton, ON, Canada; McMaster University, Department of Health Research Methods, Evidence and Impact (HEI), Hamilton, ON, Canada. Electronic address:
Background: In effort to improve post-operative outcomes, enhanced recovery after surgery (ERAS) protocols have gained popularity. The objective of this systematic review was to assess the reporting and methodological quality of plastic surgery ERAS studies.
Methods: All plastic surgery ERAS implementation studies, published between January 1, 2020, to November 20, 2023, were included.
Econ Hum Biol
December 2024
Department of Economics, McMaster University, Hamilton, Ontario, Canada. Electronic address:
Objective: The objective is to estimate the effect of provincial minimum wage increases in Canada on heavy drinking, binge drinking and average daily alcohol consumption.
Method: We estimate standard regression models by gender-age group with drinking behaviours as the dependent variables and the minimum wage among the independent variables. We employ the Canadian National Population Health Survey which began in 1994 and ended in 2011, a period comparable to that used by many U.
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