We are now on the threshold of a major step in reducing the incidence of pertussis and its associated mortality and morbidity in young children. Assuring that vaccines are received in a timely fashion by all children and correcting the "missed opportunities" for providing this highly effective intervention are most critical. A plan for booster immunizations must be developed for older children and adults to offer further protection of young infants through the cocoon effect that this would create for them.
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Ital J Pediatr
November 2024
General Director Local Health Agency Na3 Sud , via Marconi, Torre del Greco, 66-80059, Italy.
Vaccination is a crucial tool for the primary prevention of infectious diseases. Thanks to the widespread of vaccinations it has been possible to eradicate very serious diseases. Unfortunately, vaccination coverage in Italy has been decreasing starting from 2015, getting worse during COVID-19.
View Article and Find Full Text PDFIran J Allergy Asthma Immunol
July 2024
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Acellular pertussis vaccines (aPVs) have been developed as an alternative to whole-cell pertussis vaccines (wPVs) due to their similar efficacy but reduced reactogenicity. The aPV contains three or more immunogenic components of BP. We aimed to evaluate the immunogenicity and protective potency of an aPV vaccine produced in our laboratory consisting of pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (PRN) in mice.
View Article and Find Full Text PDFVaccine X
October 2024
Center for Infectious Disease Control (CIb), National Institute for Public Health and the Environment (RIVM), The Netherlands.
National Immunisation Programmes (NIPs) develop historically. Its performance (disease incidences, vaccination coverage) is monitored. Reviewing the schedule as a whole could inform on further optimisation of the programme, i.
View Article and Find Full Text PDFVaccines (Basel)
August 2024
World Health Organization, South-East Asia Region, New Delhi 110001, India.
The Government of India, in collaboration with the World Health Organization (WHO), established the National Polio Surveillance Project (NPSP) in 1997 and initiated acute flaccid paralysis (AFP) surveillance to achieve the goal of polio eradication. The WHO South-East Asia Region, comprising of 11 countries, including India, was certified as polio-free in March 2014. India was also validated to have eliminated maternal and neonatal tetanus in May 2015.
View Article and Find Full Text PDFVaccine
October 2024
South African Centre for Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch, South Africa.
In the context of polio eradication efforts, accurate assessment of vaccination programme effectiveness is essential to public health planning and decision making. Such assessments are often based on zero-dose children, estimated using the number of children who did not receive the first dose of the Diphtheria-Tetanus-Pertussis containing vaccine as a proxy. Our study introduces a novel approach to directly estimate the number of children susceptible to poliovirus type 2 (PV2) and uses this approach to provide district-level estimates for South Africa of susceptible children born between 2017 and 2022.
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