In the dosimetry of boron neutron capture therapy (BNCT) beams, thermoluminescent (TL) detectors are typically applied in phantom measurements to determine the spatial distribution of the gamma ray and neutron dose. Pairs of 6LiF and 7LiF are applied to discriminate between the thermal neutron and gamma ray field components, exploiting the high cross section for (n,alpha) reaction of 6Li. At the Institute of Nuclear Physics (INP) in Kraków (Poland) a prototype TL-based measuring set has been constructed and tested. This set consists of a miniature TL detector (of 2 mm diameter and 0.4 mm thickness) placed inside a miniature container made of non-thermoluminescent 6LiF. The outer dimensions of the set are 4.5 mm diameter and 1.4 mm thickness, enabling its application in place of a thermoluminescence dosemeter pellet in typical phantoms. The detector sets were tested in the BNCT beam of the Studsvik reactor. By exploiting the ratio of TL signals of the unshielded and shielded detectors, it was possible to estimate the contributions of the thermal and epithermal components of the neutron field.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/rpd/nch218 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep Convolutional Framelets for Dose Reconstruction in Boron Neutron Capture Therapy with Compton Camera Detector.
Cancers (Basel)
January 2025
Istituto Nazionale di Fisica Nucleare, Sezione di Bari, 70125 Bari, Italy.
Background: Boron neutron capture therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction B(n,α)Li, consisting in the exposition of patients to neutron beams after administration of a boron compound with preferential accumulation in cancer cells. The high linear energy transfer products of the ensuing reaction deposit their energy at the cell level, sparing normal tissue. Although progress in accelerator-based BNCT has led to renewed interest in this cancer treatment modality, in vivo dose monitoring during treatment still remains not feasible and several approaches are under investigation.
View Article and Find Full Text PDFBiophysical modeling of low-energy ion irradiations with NanOx.
Med Phys
December 2024
Université Claude Bernard Lyon 1, CNRS/IN2P3, IP2I Lyon, UMR 5822, Villeurbanne, France.
Background: Targeted radiotherapies with low-energy ions show interesting possibilities for the selective irradiation of tumor cells, a strategy particularly appropriate for the treatment of disseminated cancer. Two promising examples are boron neutron capture therapy (BNCT) and targeted radionuclide therapy with -particle emitters (TAT). The successful clinical translation of these radiotherapies requires the implementation of accurate radiation dosimetry approaches able to take into account the impact on treatments of the biological effectiveness of ions and the heterogeneity in the therapeutic agent distribution inside the tumor cells.
View Article and Find Full Text PDFImplementation of optically simulated luminescent dosimeter for quality control of gamma ray dose of an accelerator-based neutron source.
J Appl Clin Med Phys
November 2024
Osaka Medical and Pharmaceutical University, Kansai BNCT Medical Center, Osaka, Japan.
Background: Neutron beams utilized for performing BNCT are composed of a mixture of neutrons and gamma rays. Although much of the dose delivered to the cancer cells comes from the high LET particles produced by the boron neutron capture reaction, the dose delivered to the healthy tissues from unwanted gamma rays cannot be ignored. With the increase in the number of accelerators for BNCT, a detector system that is capable of measuring gamma ray dose in a mixed neutron/gamma irradiation field is crucial.
View Article and Find Full Text PDFUltrasound Combination to Improve the Efficacy of Current Boron Neutron Capture Therapy for Head and Neck Cancer.
Cancers (Basel)
August 2024
Department of Oral & Maxillofacial Oncology and Surgery, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan.
Boron neutron capture therapy (BNCT) is radiotherapy in which a nuclear reaction between boron-10 (B) in tumor cells and neutrons produces alpha particles and recoiling Li nuclei with an extremely short range, leading to the destruction of the tumor cells. Although the neutron source has traditionally been a nuclear reactor, accelerators to generate neutron beams have been developed and commercialized. Therefore, this treatment will become more widespread.
View Article and Find Full Text PDFEfficient optimization of an accelerator neutron source for neutron capture therapy using genetic algorithms.
Med Phys
September 2024
Sino-French Institute of Nuclear Engineering and Technology, Sun Yat-sen University, Zhuhai, Guangdong, China.
Background: In recent years, genetic algorithms have been applied in the field of nuclear technology design, producing superior optimization results compared to traditional methods. They can be employed in the design and optimization of beam shaping assemblies (BSA) BSA to obtain the desired neutron beams. But it should be noted that the direct combination of Monte Carlo methods with genetic algorithms requires a significant amount of computational resources and time.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!