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Tributyl phosphate inhibits neurogenesis and motor functions during embryonic development in zebrafish.
Aquat Toxicol
December 2024
Department of Developmental Biology, Agharkar Research Institute, Pune, Maharashtra 411004, India. Electronic address:
Tributyl phosphate (TBP), an organophosphate ester (OPE), is heavily used as a solvent in chemical industries, a plasticizer, and to extract radioactive molecules. Thus, widespread uses of TBP in industrialized countries led to the release of TBP and its metabolites, dibutyl phosphate (DBP) and monobutyl phosphate (MBP), in the environment and were detected in human samples. Accumulating these OPEs over time in humans and aquatic animals may develop toxicological effects.
View Article and Find Full Text PDFDesign, green synthesis, and anti-glutamate damage screening of chalcone derivatives with spiro-heterocyclic structures as potential anti-ischemic brain and eye damage agents.
Bioorg Chem
December 2024
The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325027, China; The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address:
Article Synopsis
- - Researchers focused on reducing excessive glutamate toxicity to treat brain and retinal damage in ischemic stroke patients, developing new 3-benzoyl-4-phenyl-spiropyrrolidone compounds.
- - They screened these compounds for protective effects on PC12 cells and established a structure-activity relationship (QSAR) model with a strong correlation (R = 0.90723).
- - The best compound, E38, showed significant protective effects in cell cultures and in a mouse model, reducing brain damage and improving neurological function, indicating its potential as a treatment for ischemic stroke.
Phenylpropanoid-rich maize root extract serves as a natural antidepressant.
Phytomedicine
October 2024
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address:
Background: Depression is a serious and complex mental disease that has attracted worldwide attention because of its high incidence rate, high disability rate and high mortality. Excitotoxicity is one of the most important mechanisms involved in the pathophysiological process of depression. In our previous studies, n-butanol extract from maize roots was found to have good neuroprotective effects due to its antioxidative activity.
View Article and Find Full Text PDFSleep quality in patients with chronic spontaneous urticaria and relation with Orexin-A, leptin, and ghrelin.
Allergy Asthma Proc
July 2024
Department of Dermatology, University of Health Sciences Ankara Training and Research Hospital, Ankara, Turkey.
Article Synopsis
- Chronic spontaneous urticaria (CSU) may impact sleep quality, but the link between sleep regulation mechanisms and CSU is not well understood, particularly concerning orexin-A, ghrelin, and leptin.
- A study involving 33 CSU patients and 34 controls measured serum levels of orexin-A, ghrelin, and leptin, alongside various sleep quality assessments.
- Results showed higher levels of serum orexin-A and leptin in CSU patients versus controls, with orexin-A levels positively correlating with sleep quality, suggesting its potential influence in sleep disturbances among CSU patients.
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B.
Cell Mol Life Sci
July 2024
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology, Barcelona, Spain.
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with sleeping disorders, and non-peptide drugs are currently being developed to treat insomnia and narcolepsy. Yet, no light-regulated agents are available to reversibly control their activity.
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