The aerial parts of Anvillea radiata yielded a new germacranolide, 8alpha,9alpha-epoxyparthenolide (3), together with two known compounds, 9alpha-hydroxyparthenolide (1) and parthenolid-9-one (2). The structures of the compounds were elucidated from IR, HRMS, 1H and 13C-NMR, COSY, HETCOR, HMBC and HOHAHA spectral data. The major component 1 was tested for its cytotoxicity and antibacterial activity.
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http://dx.doi.org/10.1016/j.fitote.2004.06.003 | DOI Listing |
J Environ Sci Health A Tox Hazard Subst Environ Eng
March 2022
Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, Errachidia, Morocco.
As an alternative strategy in combating the COVID-19 pandemic, phytoconstituents from medicinal plants are getting attention worldwide. The current investigation focused on the efficacy of the essential phytocompounds identified in to target the main protease (M) of SARS-COV-2 through molecular docking and dynamic analyses; in addition to the safety assessment of this herb . , the 6LU7 structure of M was prepared as a target by Discovery Studio 2020.
View Article and Find Full Text PDFEndocr Metab Immune Disord Drug Targets
June 2021
Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000. Errachidia, Morocco.
Objective: This study aimed to evaluate the effect of the aqueous extract of Anvillea radiate (A. radiata) aerial parts (AEAR) on arterial blood pressure in normotensive and hypertensive rats.
Methods: The effect of the acute and sub-chronic administration of AEAR on the following blood pressure parameters: systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP), and heart rate (HR) was evaluated in normotensive and L-NAME induced hypertensive rats.
Cardiovasc Hematol Disord Drug Targets
March 2019
Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, 52000, Errachidia, Morocco.
Introduction: Anvillea radiata Coss. & Durieu (Asteraceae) is an endemic plant from North Africa (Morocco and Algeria). This plant has many traditional uses including treatment of obesity and diabetes.
View Article and Find Full Text PDFJ Ethnopharmacol
July 2017
Aix Marseille Univ, CNRS, ICR, SMBSO, Marseille, France. Electronic address:
Ethnopharmacological Relevance: According to Saharian traditional medicine, Anvillea radiata Coss. & Dur. (Asteraceae) has been valued for treating a variety of ailments such as gastro-intestinal, liver and pulmonary diseases, and has gained awareness for its beneficial effect on postprandial hyperglycemia.
View Article and Find Full Text PDFPlanta Med
May 2017
Laboratoire de Chimie Physique & de Chimie Bioorganique, URAC 22, Université Hassan II Casablanca, Mohammedia, Morocco.
Motivated by the widely reported anticancer activity of parthenolides and their derivatives, a series of new substituted parthenolides was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9- and 9-hydroxyparthenolide, which were isolated from the aerial parts of . Twenty-one derivatives were synthesized and evaluated for their cytotoxic activity against HS-683, SK-MEL-28, A549, and MCF-7 human cancer cell lines using the MTT colorimetric assay.
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