A polarographic study about how three anti-inflammatories, such as Aceclofenac, Tenoxicam and Droxicam behave, using tast polarography (TP) and differential pulse polarography (DPP) was carried out. These studies were always carried out in a media formed by Methanol-Britton-Robinson aqueous buffer (0.1M) (4:96 (v/v)) due to the low solubility of these drugs in water. A strong influence of pH on analytical signals was observed, showing that the optimal pH values were between 4 and 5. Using DPP in the optimal experimental conditions, a detection limit of 10 ppb for Tenoxicam and Droxicam and 52 ppb for Aceclofenac was reached. The DPP proposed method was successfully applied to the determination of the active compounds in commercial drugs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpba.2004.04.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ultrasensitive and simultaneous detection of 6 nonsteroidal anti-inflammatory drugs by colloidal gold strip sensor.
J Dairy Sci
March 2021
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214121, People's Republic of China; International Joint Research Laboratory for Biointerface and Biodetection, and School of Food Science and Technology, Jiangnan University, Wuxi 214121, People's Republic of China. Electronic address:
In this work, an oxicam group-selective monoclonal antibody against 6 nonsteroidal anti-inflammatory drugs (NSAID; meloxicam, lornoxicam, piroxicam, sudoxicam, droxicam, and tenoxicam) was prepared. Also, a spacer arm with carboxyl group was derived at the hydroxyl of meloxicam to generate the meloxicam hapten. The half-maximal inhibitory concentrations (IC) were, respectively, 0.
View Article and Find Full Text PDFComputational nanochemistry report on the oxicams--conceptual DFT indices and chemical reactivity.
J Phys Chem B
May 2013
Dirección de Investigación y Desarrollo, Universidad Pedro de Valdivia, Sede Santiago, Campus Tobalaba, Santiago, Chile.
A density functional theory study of eight oxicams was carried out in order to determine their global and local reactivities. These types of reactivities were measured by means of global and local reactivity descriptors coming from the conceptual density functional theory. Net electrophilicity as a global reactivity descriptor and local hypersoftness as a local reactivity descriptor were the used tools to distinguish reactivity and selectivity among these oxicams.
View Article and Find Full Text PDFNon-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems.
Fundam Clin Pharmacol
August 2006
Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, EA3696, Université Paul Sabatier, Toulouse, France.
Several non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with liver damage. The aim of this study was to compare proportions of hepatic adverse drug reaction reports associated with NSAIDs in France and Spain. Information from the Spanish and French pharmacovigilance databases were used from 1982 to 2001.
View Article and Find Full Text PDFPolarographic behaviour of Aceclofenac, Tenoxicam and Droxicam in a methanol-water mixture.
J Pharm Biomed Anal
September 2004
Department of Analytical Chemistry, Faculty of Sciences, University of Valladolid, Analytical Chemistry, C Prado de la Magdalena sn, Valladolid, Spain.
A polarographic study about how three anti-inflammatories, such as Aceclofenac, Tenoxicam and Droxicam behave, using tast polarography (TP) and differential pulse polarography (DPP) was carried out. These studies were always carried out in a media formed by Methanol-Britton-Robinson aqueous buffer (0.1M) (4:96 (v/v)) due to the low solubility of these drugs in water.
View Article and Find Full Text PDFPiroxicam-induced photodermatitis. Cross-reactivity among oxicams. A case report.
Allergol Immunopathol (Madr)
December 2001
Gregorio Marañón Hospital, Madrid, Spain.
Background: there is a group of patients with contact allergy to thimerosal (thiosalicylic acid and ethylmercuric chloride), thiosalicylic acid sensitized, who develop photodermatitis to piroxicam. We present a case which we have investigated cross-reactivity among different oxicams.
Methods And Results: a 44-year-old man with contact allergy to thimerosal.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!