Identification of 5-aminosalicylic acid, ciprofloxacin and azithromycin by abrasive stripping voltammetry.

J Pharm Biomed Anal

Center for Marine and Environmental Research, Rudjer Bosković Institute, Bijenicka 54, P.O. Box 180, 10002 Zagreb, Croatia.

Published: September 2004

Solid microparticles of 5-aminosalicylic acid, ciprofloxacin, and azithromycin were mechanically immobilized on the surface of the paraffin impregnated graphite electrode and investigated by square-wave and cyclic voltammetry in order to develop a method for their qualitative determination. 5-Aminosalicylic acid is oxidized at 0.540 V in the quasireversible electrode reaction, which is followed by the chemical transformation of the product, while ciprofloxacin and azithromycin are oxidized at 1.2 V and 0.94 V, respectively, in totally irreversible electrode reactions. The detection of these drugs in commercial dosage formulations is reported.

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http://dx.doi.org/10.1016/j.jpba.2004.05.008DOI Listing

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