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Thyroid hormones reversibly inhibit metamorphic development in ophiuroid larvae.
J Exp Biol
January 2025
University of Guelph, 50 Stone Rd E, Guelph, N1G 2M7, Canada.
The timing of metamorphosis and settlement is critical for the survival and reproductive success of marine animals with biphasic life cycles. Thyroid hormones (THs) regulate developmental timing in diverse groups of chordates, including the regulation of metamorphosis in amphibians, teleosts, lancelets, tunicates, and lampreys. Recent evidence suggests a role for TH regulation of metamorphosis outside of the chordates, including echinoderms, annelids, and molluscs.
View Article and Find Full Text PDFOrthodontic Treatment Need and Its Relation to Gender, Oral Hygiene, and Age Range in a Mexican Population.
Cureus
December 2024
Clinical Research Laboratory, Faculty of Stomatology, Autonomous University of San Luis Potosí, San Luis Potosí, MEX.
Introduction Malocclusion, a prevalent oral health concern, significantly impacts both functional abilities and psychosocial well-being. The Dental Aesthetic Index (DAI) is widely used to assess malocclusion severity and orthodontic treatment needs. This study aims to evaluate the prevalence of orthodontic treatment needs based on the DAI in a Mexican population, considering factors such as gender, oral hygiene, and age range.
View Article and Find Full Text PDFImpact of strategic public health interventions to reduce tuberculosis incidence in Brazil: a Bayesian structural time-series scenario analysis.
Lancet Reg Health Am
January 2025
Curso de Medicina, Universidade Salvador, Salvador, Brazil.
Background: Despite government efforts, tuberculosis (TB) remains a major public health threat in Brazil. In 2023, TB incidence was 39.8 cases per 100,000 population, far above the WHO's target of 6.
View Article and Find Full Text PDFBarriers and challenges of establishing family physician policy for urban population; evidence from a qualitative study in Iran.
J Prev Med Hyg
September 2024
School of Health Sciences, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Background: Family physicians play a crucial role in healthcare delivery systems worldwide. In Iran, the family physician program has been introduced in only two provinces, with its expansion to other regions currently stalled due to various challenges. This study aims to identify the barriers and challenges hindering the effective implementation of the family physician program in urban areas of Iran.
View Article and Find Full Text PDFSingle-Molecule Tracking and Super-Resolution Microscopy Unveil Actin-Driven Membrane Nanotopography Shaping Stable Integrin Adhesions in Developing Tissue.
Cytoskeleton (Hoboken)
January 2025
Interdisciplinary Institute for Neuroscience, Université Bordeaux, CNRS, Bordeaux, France.
Single molecule tracking and super-resolution microscopy of integrin adhesion proteins and actin in developing Drosophila muscle attachment sites reveals that nanotopography triggered by Arp2/3-dependent actin protrusions promotes stable adhesion formation. The nanodomains formed during this process confine the diffusion of integrins and promote their immobilization. Spatial confinement is also applied to the motion of actin filaments, resulting in enhanced mechanical connection with the integrin adhesion complex.
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