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Chromatin Topological Domains Associate With the Rapid Formation of Tandem Duplicates in Plants.
Adv Sci (Weinh)
December 2024
School of Advanced Agriculture Sciences and School of Life Sciences, Academy for Advanced Interdisciplinary Studies, State Key Laboratory of Protein and Plant Gene Research, Peking University, Beijing, 100871, China.
In eukaryotes, chromatin is compacted within nuclei under the principle of compartmentalization. On top of that, condensin II establishes eukaryotic chromosome territories, while cohesin organizes the vertebrate genome by extruding chromatin loops and forming topologically associating domains (TADs). Thus far, the formation and roles of these chromatin structures in plants remain poorly understood.
View Article and Find Full Text PDFA Benign Lesion of Thyroid Masquerading as a Salivary Gland Malignancy on Cytology.
Diagn Cytopathol
December 2024
Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Introduction: Thyroid lesions are one of the most common diseases observed in clinical practice in the North India. These diseases have distinct cytological morphology and thus FNAC is done frequently. Here we report a case of adenomatoid goitre mimicking adenoid cystic carcinoma (ACC) of salivary gland on cytology.
View Article and Find Full Text PDFRat Liver Perfusion and Primary Hepatocytes Isolation: An Old Procedure Crucial for Cutting-Edge 3D Organoids Culture.
J Vis Exp
November 2024
Italian Liver Foundation;
Primary hepatocytes are a commonly used tool for in vitro liver-related studies. However, the maintenance of these cells has always been a challenge due to the rapid loss of morphology, viability, and functionality in culture. A recent approach to long-term culture is the generation of three-dimensional (3D) organoids, an in vitro tool that can recapitulate tissues in a dish based on the marvelous ability of the liver to regenerate itself.
View Article and Find Full Text PDFCytologic features of gastric-type endocervical adenocarcinoma: Three cases report and literature review.
Medicine (Baltimore)
October 2024
Department of Pathology, Yueyang Central Hospital, Yueyang City, Hunan Province, China.
Rationale: Cervical gastric-type adenocarcinoma shows gastric differentiation, and the tumor cell morphology appears benign and unrelated to human papillomavirus, which makes cervical gastric-type adenocarcinoma highly susceptible to misdiagnosis as normal glandular epithelium in cytologic diagnosis.
Patient Concerns: We present 3 cases of gastric-type adenocarcinoma, with the first being a 57-year-old female with abnormal uterine bleeding and fluid drainage. The second patient was a 63-year-old female, and the third was a 59-year-old female with irregular vaginal bleeding after menopause.
Cytologic diagnosis and differential diagnosis of histiocytic signet ring cells in effusion specimens.
Cytojournal
September 2024
Department of Pathology, The Johns Hopkins Hospital, Baltimore, United States.
Article Synopsis
- The study investigates benign histiocytic proliferation in effusions, noting its similarities to diseases like rheumatoid arthritis and lupus, while highlighting potential confusion with malignant tumors.
- Out of 755 benign effusion cases analyzed over a year, 35 cases exhibited histiocytic signet ring cell features, emphasizing the importance of correct diagnosis.
- Key characteristics of these benign histiocytes include clear cytoplasm, eccentric nuclei, and a specific morphology that distinguishes them from malignant cells, confirmed through immunohistochemical staining.
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