The NMR relaxivity of proton by dextran-magnetite (DM) complex was examined at temperatures from 20 to 80 degrees C. The decrease in T1 relaxivity with increasing temperature is due to the thermal activation of motion of water molecules in and/or surrounding DM particle. The decrease in magnetization of magnetite core is the secondary effect. The temperature dependence of T1 relaxivity was found to depend on molecular weight of dextran. The motion of dextran chains binding to core may affect the thermal activation of "heavy water" interacted with dextran. The Arrhenius plots of T1 relaxivity showed different slopes at 20-40 degrees C and 50-80 degrees C, while, no change in slope was observed for Fe(NO3)3, CuSO4 and Gd-DTPA solutions.
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http://dx.doi.org/10.1023/a:1013663309228 | DOI Listing |
Int J Nanomedicine
August 2010
Department of Radiology, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
We developed a dextran-magnetite conjugated cisplatin (DM-Cis) complex for use in thermal ablation and as a chemotherapeutic drug. To produce DM-Cis we reacted Cis with 1 mL DM (56 mg/mL iron). The temperature rise of DM-Cis was measured in vitro and in vivo under a portable induction-heating (IH) device.
View Article and Find Full Text PDFOral Dis
March 2007
Department of Dentistry and Oral Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Objective And Methods: This study was performed to clarify the usefulness of inductive heating system for the new endodontic therapy. Dextran magnetite complex (DM) suspensions were injected into the root canal of a permanent tooth, and the tooth was heated up to about 55.0 degrees C by alternating-current magnetic field.
View Article and Find Full Text PDFJ Mater Sci Mater Med
February 2001
Instrument and Analysis Center, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan.
Three kinds of dextran-magnetite (DM) complexes were prepared using alkali-treated dextrans with molecular weights of 1900, 4200 and 9600, respectively. The number of dextrans binding to a magnetite core was determined. The number was proportional to the area of core surface and the area occupied by a dextran was 2.
View Article and Find Full Text PDFJ Mater Sci Mater Med
January 2002
Instrument and Analysis Center, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan.
The NMR relaxivity of proton by dextran-magnetite (DM) complex was examined at temperatures from 20 to 80 degrees C. The decrease in T1 relaxivity with increasing temperature is due to the thermal activation of motion of water molecules in and/or surrounding DM particle. The decrease in magnetization of magnetite core is the secondary effect.
View Article and Find Full Text PDFJ Mater Sci Mater Med
January 2000
Instrument and Analysis Center, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan.
A homologous series of dextran-magnetite complex (DM) was synthesized using alkali-treated dextrans with various molecular weights from 1800 to 27000. The structure of DM particles in water, particularly effect on molecular weight of dextran, was studied. The number of dextran chains binding to a core is possibly determined by the steric hindrance between dextran chains covering core.
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