Since 1991 infrequent reports have described a distinctive triad of nodulocystic acne, striking follicular spines and an eruption resembling pityriasis rubra pilaris (PRP) in HIV-positive patients. It has been suggested that this may represent a subtype of PRP, or alternatively that it should be viewed as a unique HIV-associated follicular occlusion triad. Clinical manifestations may be severe, and in several cases have been ultimately fatal, with death occurring due to complications of cutaneous sepsis. We describe a case demonstrating severe conglobate acne, follicular keratotic spines and histologically confirmed PRP in association with HIV infection. Clinical features and treatment modalities of previously reported cases are reviewed. Despite refusing all topical and systemic treatment our patient showed spontaneous remission of skin signs after 2 years.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-2230.2004.01571.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of the genomic landscape of HIV-associated lymphoma reveals heterogeneity across histological subtypes.
AIDS
November 2024
Department of Hematology, Aarhus University Hospital.
Article Synopsis
- Individuals with HIV have a heightened risk of developing lymphoma, a significant cause of death, but the genetic factors involved are not well understood.
- Researchers performed next-generation sequencing on lymphoma biopsies from 18 HIV-infected patients to analyze the genetic mutations present in these tumors.
- The study revealed a diverse range of 213 genetic variants across the lymphomas, with no consistent mutations shared among all cases, indicating complex genetic heterogeneity in HIV-associated lymphomas.
PET/CT in a 65-Year-Old Woman With Epstein-Barr Virus-Associated Smooth Muscle Tumor After Chemotherapy for Follicular Lymphoma.
Clin Nucl Med
May 2024
Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
The Epstein-Barr virus-associated smooth muscle tumor (SMT) is an uncommon neoplasm. It arises mainly in 3 immunosuppression settings: HIV-associated SMT; drug-related immunosuppression in transplant recipients; and congenital immunodeficiency disorder-associated SMT. We present 18 F-FDG PET/CT findings of an adrenal Epstein-Barr virus-associated SMT in a 65-year-old woman with a history of follicular lymphoma after chemotherapy.
View Article and Find Full Text PDFCOVID-19 and HIV-Associated Immune Reconstitution Inflammatory Syndrome: Emergence of Pathogen-Specific Immune Responses Adding Fuel to the Fire.
Front Immunol
April 2021
School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Both coronavirus disease 2019 (COVID-19) and mycobacterial immune reconstitution inflammatory syndrome (IRIS) in patients with HIV-1 infection result from immunopathology that is characterized by increased production of multiple pro-inflammatory chemokines and cytokines associated with activation of myeloid cells (monocytes, macrophages and neutrophils). We propose that both conditions arise because innate immune responses generated in the absence of effective adaptive immune responses lead to monocyte/macrophage activation that is amplified by the emergence of a pathogen-specific adaptive immune response skewed towards monocyte/macrophage activating activity by the immunomodulatory effects of cytokines produced during the innate response, particularly interleukin-18. In mycobacterial IRIS, that disease-enhancing immune response is dominated by a Th1 CD4 T cell response against mycobacterial antigens.
View Article and Find Full Text PDFParaneoplastic pityriasis rubra pilaris in association with prostate carcinoma: A case report and literature review.
Exp Ther Med
December 2019
CMI Dermamed, 530540 Târgu Mureş, Romania.
Pityriasis rubra pilaris (PRP) is a chronic papulosquamous disorder of unknown etiology, characterized by reddish orange scaly plaques, islands of sparing, palmoplantar keratoderma, and keratotic follicular papules. The disease can be acquired or inherited, being divided into 5 categories: classic adult type, atypical adult type, classic juvenile type, circumscribed juvenile type, and atypical juvenile type. More recently, an HIV-associated type has been added to this classification.
View Article and Find Full Text PDFThe life and death of the germinal center.
Ann Diagn Pathol
February 2020
NeoGenomics, Aliso Viejo, CA, United States of America; Department of Hematopathology, M.D. Anderson Cancer Center, Houston, TX, United States of America. Electronic address:
The formation, development and dissolution of germinal centers is a major part of immune system function. It is important to differentiate neoplastic processes from follicular hyperplasia and regressive follicular changes. Better understanding of germinal center development and dissolution also provides diagnostic clues to the underlying pathologic process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!