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Exploring the Effects of Tomatidine ((3β, 5α, 22β, and 25β)-Spirosolan-3-ol) on Voltage-gated Na+ currents: Insights Into Its Ionic Mechanisms of Action on Current Magnitude, Gating, and Frequency Dependence.
J Physiol Investig
November 2024
Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.
Tomatidine, a major tomato glycoalkaloid, is effective for the prevention of skeletal muscle wasting and enhancing mitophagy. However, its effects on transmembrane ionic currents are not well explored. In this study, we explored the interactions between tomatidine and Na+ current.
View Article and Find Full Text PDFStable Angina Pectoris: A Review of Pathophysiology, Diagnosis, and Its Management.
J Assoc Physicians India
November 2024
Director, Department of Medical Affairs, Dr Reddy's Laboratories Ltd., Ameerpet, Hyderabad, Telangana, India.
Article Synopsis
- India faces a growing epidemic of cardiovascular diseases, particularly coronary artery disease, due to rapid urbanization and globalization, with over 7 million deaths annually from CAD.
- Key challenges in low- and middle-income countries include a lack of awareness about risk factors, healthcare access, and affordability of treatment.
- Effective management of angina pectoris involves collaboration among patients and healthcare providers and utilizes both first-line (like CCBs and β-blockers) and second-line antianginal medications to improve patient outcomes.
The role of coronary microcirculation in heart failure with preserved ejection fraction: An unceasing odyssey.
Heart Fail Rev
January 2025
First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital, Vasilissis Sofias 114, 11528, Athens, PO, Greece.
Heart failure with preserved ejection fraction (HFpEF) represents an entity with complex pathophysiologic pathways, among which coronary microvascular dysfunction (CMD) is believed to be an important orchestrator. Research in the field of CMD has highlighted impaired vasoreactivity, capillary rarefaction, and inflammation as potential mediators of its development. CMD can be diagnosed via several noninvasive methods including transthoracic echocardiography, cardiac magnetic resonance, and positron emission tomography.
View Article and Find Full Text PDFBackground: Famotidine is a competitive histamine H-receptor antagonist that reduces the formation of stomach acid and is used to treat gastrointestinal disorders associated with acid reflux, gastroesophageal reflux disease, duodenal ulcer, gastric ulcer, and pathological hypersecretory disorders. This study is designed to investigate the possible neuroprotective effects of the ranolazine scopolamine-induced Alzheimer's disease-like feature in a mouse model.
Methods: Mice were divided equally into five groups (ten mice per group), including control group and induction group.
Effects of Ranolazine and Ivabradine on Pulmonary Microhemodynamics in Experimental Model of Pulmonary Thromboembolism.
Bull Exp Biol Med
June 2024
Laboratory of Physiology of Visceral Systems, Institute of Experimental Medicine, St. Petersburg, Russia.
We studied changes of pulmonary microhemodynamics when modeling pulmonary artery thromboembolism on perfused isolated rabbit lungs after pretreatment with ranolazine and ivabradine. The increase in pulmonary artery pressure, pulmonary vascular resistance, and pre- and postcapillary resistance was less pronounced than in control animals, but was close to that in case of pulmonary thromboembolism after pretreatment with voltage-gated Na channel blockers lidocaine and ropivacaine. The increase of capillary filtration coefficient inversely correlated with values of capillary hydrostatic pressure.
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