AI Article Synopsis
- Conducted a comparative genomic analysis of Mycobacterium avium subspecies using DNA microarray technology, identifying 14 large sequence polymorphisms (LSPs) spanning over 700 kb.
- These LSPs effectively differentiate M. avium subsp. avium from M. avium subsp. paratuberculosis, with a notable emphasis on genes related to metabolic pathways.
- Found a specific polymorphism in the mycobactin biosynthesis operon, which may explain why M. avium subsp. paratuberculosis is dependent on mycobactin in laboratory conditions.
Article Abstract
We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515132 | PMC |
| http://dx.doi.org/10.1128/JB.186.18.6332-6334.2004 | DOI Listing |
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