AI Article Synopsis
- Chronic restraint stress early in infection with Theiler's virus worsened acute central nervous system viral infection and the later demyelinating phase in mice, serving as a model for Multiple Sclerosis.
- Stressed mice showed significant health issues, including reduced body weight and activity, along with elevated plasma corticosterone levels, indicating stress.
- During the chronic phase, these mice exhibited more severe symptoms, poorer motor performance, increased inflammatory lesions in the spinal cord, and developed autoantibodies linked to myelin-related proteins.
Article Abstract
Chronic restraint stress, administered during early infection with Theiler's virus, was found to exacerbate the acute central nervous system (CNS) viral infection and the subsequent demyelinating phase of disease (an animal model of Multiple Sclerosis (MS)) in SJL male and female mice. During early infection, stressed mice displayed decreased body weights and spontaneous activity; while increased behavioral signs of illness and plasma corticosterone (CORT) levels. During the subsequent chronic demyelinating phase of disease, previously stressed mice had greater behavioral signs of the chronic phase, worsened rotarod performance, and increased inflammatory lesions of the spinal cord. In addition, mice developed autoantibodies to myelin basic protein (MBP), proteolipid protein peptide (PLP139-151), and myelin oligodendrocyte glycoprotein peptide (MOG33-55).
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| http://dx.doi.org/10.1016/j.jneuroim.2004.06.006 | DOI Listing |
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