Synthesis and evaluation of novel oxazoline MMP inhibitors.

Bioorg Med Chem Lett

Center for Protease Research, Department of Chemistry, Biochemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105, USA.

Published: October 2004

MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases.

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http://dx.doi.org/10.1016/j.bmcl.2004.07.023DOI Listing

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