AI Article Synopsis
- A new series of chemicals called N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acids were created and tested for their ability to bind to and block prostaglandin D(2) receptors.
- Some of these compounds showed strong binding to the receptors and effectively reduced levels of cAMP, a molecule involved in many cellular processes.
- Additionally, these antagonist chemicals were able to decrease allergic responses, specifically preventing the increase in microvascular permeability caused by PGD(2).
Article Abstract
A series of N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acids were synthesized and evaluated for prostaglandin D(2) (DP) receptor affinity and antagonist activity. Some of them exhibited strong receptor binding and were potent in the cAMP formation assays. These antagonists also suppressed allergic inflammatory responses such as the PGD(2)-induced increase of microvascular permeability. Structure-activity relationship (SAR) data are presented.
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| http://dx.doi.org/10.1016/j.bmcl.2004.07.039 | DOI Listing |
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