Dynamics of effective and general concentration of albumins and middle-size molecules in blood plasma of patients with severe pancreonecrosis is described. Significant differences of these data in operated and non-operated patients are revealed. A negative correlation between severity of pancreatic necrosis and concentrations of albumins, and a direct correlation between necrotic lesion and concentration of middle-size molecules in blood plasma were demonstrated. The above parameters are important for assessment of treatment efficacy, prognosis of postoperative complications and determination of indications to sanated relaparotomies in patients with pancreonecrosis.

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