The effect of camellia oil on the permeation of flurbiprofen (FP) and diclofenac sodium (DFS), used as model drugs, through rat and pig skin was examined. Two different types of camellia oil were used: one of them was purified by distillation and the other was purified by filtration without heating. The distilled camellia oil (DCO) and the filtered camellia oil (FCO) were applied to the skin as a pretreatment. Permeation of FP through the skins pretreated with FCO and DCO was enhanced, while that of DFS was suppressed. The effects of FCO were greater than those of DCO as far as enhancement and suppression were concerned. The effect of FCO on FP permeation could be due to oleic acid, one of the major components of FCO. On the other hand, FCO and oleic acid had opposite effects on the penetration of DFS. This result suggests that other active components which suppress the permeation of DFS may be present in FCO. Since the penetration-suppressing agents will be useful for skin care products, studies of such agents will be important in the future.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/bpb.27.1476 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of Abel.
Pharmaceuticals (Basel)
January 2025
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Background: Abel () is widely cultivated and serves as an important source of edible oil. Yet, during oil production, pruned branches generate significant waste and contribute to environmental pollution.
Objectives: In this work, we obtain a natural polysaccharide from the branches of and optimize its extraction using Box-Behnken design (BBD), which is a statistical method commonly used in response surface methodology.
Comparative Analysis of Complete Chloroplast Genomes and Phylogenetic Relationships of 21 Sect. ( L.) Plants.
Genes (Basel)
January 2025
College of Forestry, Guizhou University, Guiyang 550025, China.
: Section is the most diverse group in the genus L., and this group of plants has a long history of cultivation in China as popular ornamental flowers and oil plants. Sect.
View Article and Find Full Text PDFEffects of Functional Red Pine Seed Direct-Drinking Oil on Constipation and Intestinal Barrier Function in Mice.
Antioxidants (Basel)
December 2024
College of Food Engineering, Harbin University of Commerce, Harbin 150028, China.
Constipation is a prevalent global health issue that greatly affects human well-being. However, many existing treatments are associated with side effects, necessitating the development of alternative approaches. In this study, a balanced fatty acid red pine seed direct-drinking oil (SFA:MUFA:PUFA = 1.
View Article and Find Full Text PDFCamellia saponin modulates oleic acid/linoleic acid-induced lipogenesis in human sebocytes through lipophagy activation.
Int J Cosmet Sci
January 2025
School of Chemical and Material Engineering, Jiangnan University, Wuxi, China.
Background: Oily skin not only threatens people with aesthetic and hygienic discomfort but also confronts them with annoying skin problems. To explore new skin care ingredients from herbal or plant extracts and understand their underlying mechanism for sebum control would assist in the discovery of desirable sebosuppressive agents, though it is still a deserving and challenging task.
Aim: To explore the effect of Camellia saponin (CS) on modulating the lipogenesis of human sebocytes.
De novo assembly of the complete mitochondrial genomes of two Camellia-oil tree species reveals their multibranch conformation and evolutionary relationships.
Sci Rep
January 2025
The Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees, Ministry of Education, Central South University of Forestry and Technology, Changsha, 410004, China.
Camellia-oil trees are economically valuable, oil-rich species within the genus Camellia, family Theaceae. Among these species, C. oleifera, a member of Section Oleifera in the genus, is the most extensively cultivated in China.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!