[Effect of Zhenju Jiangya Tablet on the endothelial function of hyperlipidemic rabbits].

Zhong Xi Yi Jie He Xue Bao

Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, China.

Published: March 2004

AI Article Synopsis

  • This study examines how Zhenju Jiangya Tablet (ZJ) affects damaged endothelial cells and relaxation function in rabbits with high cholesterol.
  • Male New Zealand rabbits were divided into four groups: a control group, a hyperlipidemia group, a group receiving ZJ, and a group receiving simvastatin.
  • Results show that ZJ improved endothelial cell health and function, indicating its potential benefits for treating hyperlipidemia-related vascular issues.

Article Abstract

Objective: To study the effect of Zhenju Jiangya Tablet (ZJ) on the injured endothelial cells and endothelium-dependent relaxation function of hyperlipidemia rabbits.

Methods: Male New Zealand rabbits were randomized into four groups: control group, hyperlipidemia group, ZJ group and sivastatin group. The endothelium-dependent relaxation function was evaluated by APV using intravascular Doppler, and the morphology of endothelial cells was detected by light microscopy and electron microscopy, and nitric oxide synthase was evaluated.

Results: ZJ reduced the lesions of hyperlipidemia vessels, and the APV after Ach injection of each group was (1.14+/-0.26), (1.74+/-0.59), (1.22+/-0.37) and (1.17+/-0.41) respectively. The eNOS of each group was (4.21+/-0.37), (1.43+/-0.88), (3.95+/-0.67) and (4.08+/-0.46) nmol x min(-1) x g(-1) respectively.

Conclusion: ZJ can improve the abnormality of endothelial cells and endothelium-dependent relaxation function of hyperlipidemia.

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Source
http://dx.doi.org/10.3736/jcim20040210DOI Listing

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