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Sacubitril/Valsartan for Blood Pressure Lowering in Non-Dialysis-Dependent Chronic Kidney Disease Stage 3-5 Patients With Hypertension: A Multicenter Clinical Study.
J Clin Hypertens (Greenwich)
January 2025
Department of Nephrology, Southeast University Zhongda Hospital, Southeast University School of Medicine, Nanjing, China.
To assess the effectiveness and safety of Sacubitril/Valsartan in reducing blood pressure in individuals with non-dialysis-dependent chronic kidney disease (NDD-CKD) Stage 3-5 complicated by hypertension. This study was a multicenter retrospective analysis conducted from March 1, 2022 to March 31, 2024, involving adult patients with NDD-CKD Stage 3-5 and hypertension, who received Sacubitril/Valsartan either as a monotherapy or in addition to current antihypertensive treatments that were insufficient. The main outcomes measured were blood pressure control, changes in blood pressure and laboratory parameters within 8 weeks post-treatment initiation, and incidence of adverse events.
View Article and Find Full Text PDFMeeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance.
Transplantation
January 2025
Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Receptor-like Kinase GOM1 Regulates Glume-Opening in Rice.
Plants (Basel)
December 2024
College of Agronomy, Hunan Agricultural University, Changsha 410128, China.
Glume-opening of thermosensitive genic male sterile (TGMS) rice ( L.) lines after anthesis is a serious problem that significantly reduces the yield and quality of hybrid seeds. However, the molecular mechanisms regulating the opening and closing of rice glumes remain largely unclear.
View Article and Find Full Text PDFCross-Cultural Adaptation and Validation of the Central Sensitization Inventory Among Chinese Patients with Chronic Non-Specific Low Back Pain.
J Pain Res
December 2024
Department of Knee Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shanxi Province, People's Republic of China.
Purpose: This research aims to develop and validate the Chinese version of the Central Sensitization Inventory (CSI-CV) for patients suffering from chronic non-specific low back pain (CNSLBP). The study evaluates both the validity and reliability of the CSI-CV.
Patients And Methods: The cross-cultural adaptation of the scale strictly adhered to the principles of Bombardier and Beaton.
Effects of the combination of Epimedium brevicornum Maxim, Ligustrum lucidum Ait and Dexamethasone on asthmatic rats by endogenous glucocorticoid pathway.
J Ethnopharmacol
January 2025
School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address:
Ethnopharmacological Relevance: The theory of traditional Chinese medicine (TCM) believes that kidney deficiency is the fundamental cause of chronic refractory asthma, accompanied by pathological changes such as airway remodeling and a reduction of endogenous glucocorticoid (GC) synthesis. The combination of Epimedium brevicornum Maxim (EB) and Ligustrum lucidum Ait (LL) is frequently used in TCM for kidney tonifying and the alleviation of asthma symptoms. This approach is based on Pei-Ben formula, a renowned treatment for asthma developed by the distinguished Shanghai Practitioner, Professor Huiguang Xu, over 30 years of clinical experience.
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