AI Article Synopsis
- The study aimed to investigate the relationship between the ACE gene's insertion/deletion (I/D) polymorphism and cardiovascular health markers like ambulatory blood pressure, left ventricular mass index, and carotid intima-media thickness in families.
- The research involved 127 parents and 167 offspring who underwent blood pressure monitoring, echocardiograms, and ultrasound assessments, with the ACE polymorphism analyzed using PCR methods.
- The findings showed no significant correlation between the ACE polymorphism and the measured health parameters, although there was a slight suggestion of its influence on left ventricular mass index (P=0.06), indicating it likely does not affect these cardiovascular risk factors in the studied families.
Article Abstract
Aim: The key enzyme of the renin-angiotensin-aldosterone system angiotensin-converting enzyme (ACE), shows the genetic polymorphism responsible for the varying activity of this enzyme. In a study of randomly chosen families we analyzed the relationship between insertion/deletion (I/D) polymorphism of the ACE and ambulatory blood pressure (ABP), left ventricular mass index (LVMI) and carotid intima-media thickness (IMT).
Methods: The study population consisted of 127 parents and 167 offspring. All subjects underwent 24 hr ABP monitoring using a SpaceLabs 90207 device. 2D and M-mode echocardiograms were also obtained. The carotid intima-media thickness (IMT) was assessed by ultrasound. The I/D polymorphism of the ACE gene was measured with the use of PCR method. For statistical analysis, co-variables and correlations between relatives were taken into account.
Results: The frequency of genotypes was: 27.2% for DD homozygotes, 49.7% for DI heterozygotes and 23.1% for II homozygotes, being in Hardy-Weinberg equilibrium (P=0.97). There was no relationship between the ACE gene polymorphism and ABP, LVMI or carotid IMT in parents nor their offspring. The transmission disequilibrium tests for quantitative traits showed only a slight tendency towards the influence of the polymorphism on LVMI (P=0.06).
Conclusions: In the study group of nuclear families, I/D polymorphism of the ACE gene did not influence blood pressure, left ventricular mass or carotid intima-media thickness.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!