The first-order hydrolysis kinetics of cefetamet pivoxil (CP) were investigated as a function of pH, temperature and buffers. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles for hydrolysis of cefetamet pivoxil were obtained at 333, 343, 353 and 363K. The pH-rate expression was k(pH)=kH+aH+ + kH2OkOH-aOH-, where kH+ and kOH- are the second-order rate constants (mol(-1)ls(-1)) for hydrogen ion activity and for hydroxyl ion activity respectively, and kH2O is the pseudo-first-order rate constant (s(-1)) for spontaneous reaction under the influence of water. The pH-rate profile was characteristically U-shaped. Maximum stability was observed in the pH region from 3 to 5.
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View Article and Find Full Text PDFA fast and sensitive UHPLC-DAD method was developed and subsequently validated for determination of cefetamet pivoxil hydrochloride in the presence of its degradation products. The chromatographic separation was carried out on a Waters Acquity BEH C18, (2.1 x 100 mm, 1.
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Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China. Electronic address:
Ten impurities and isomers in cefetamet pivoxil hydrochloride drug substance made in China were separated and identified by HPLC-MS(n) (TOF and TRAP). Their fragmentation patterns and structural assignment were studied based on the HPLC-MS(n) data. Among the ten impurities and isomers, impurity VII was isolated by preparative HPLC, and its structure was confirmed by (1)H NMR data.
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Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, USA.
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