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My beloved husband, Robert Steel, died at 58 from MAPT FTD, a disease that stretches back through his family's generations. Before we married he told me his father died of early-onset Alzheimers and he was terrified he would inherit that disease. In his early 50s he began exhihibiting symptoms that I attributed to stress-his work as a respected high school teacher began to slip, he began to lose the ability to have a visual map in his head, he began to repeat stories, his behavior became more compulsive, forgot how he was related to a favorite cousin.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Financial exploitation vulnerability (FEV) denotes the risk for falling victim to financial fraud and older adults reportedly lose an estimated $36 billion annually to scams. Socioemotional and cognitive impairments are potential risk factors for FEV in older adults with dementia. The present study examines whether the socioemotional measures of sensitivity to unfairness and self-unawareness of socioemotional dysfunction and brain atrophy are associated with increased risk for FEV in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD).
View Article and Find Full Text PDFHyperactive delta isoform of PI3Kinase enables long distance regeneration of adult rat corticospinal tract.
Mol Ther
January 2025
Institute of Experimental Medicine CAS, Department of Neuroregeneration, Videnska 1083, 142 20, Prague, Czech Republic. Electronic address:
Neurons in the central nervous system (CNS) lose regenerative potential with maturity, leading to minimal corticospinal tract (CST) axon regrowth after spinal cord injury (SCI). In young rodents, knockdown of PTEN, which antagonises PI3K signalling by hydrolysing PIP3, promotes axon regeneration following SCI. However, this effect diminishes in adults, potentially due to lower PI3K activation leading to reduced PIP3.
View Article and Find Full Text PDFProfile of maladaptive and normative eating behaviors in correlation with rumination: a cross-sectional study among Lebanese adults.
Psicol Reflex Crit
January 2025
Department of Psychology and Education, School of Arts and Sciences, Lebanese American University, Jbeil, Lebanon.
Background: Dieting is a common practice around the world. People who wish to lose weight, improve their eating habits, or reach a desired level of health often diet. Rumination, a pattern of repetitive negative thoughts and emotions, is typically found when individuals diet.
View Article and Find Full Text PDFDiscovery of novel sulfonamide derivatives containing pinacolone moieties as fungicide candidates against Botrytis cinerea.
Pest Manag Sci
January 2025
Department of Pesticide Science, College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Background: Botrytis cinerea is one of the most serious plant diseases and severely threatens agricultural production. The rapidly intensifying resistance makes most commercial chemical fungicides lose control efficacy. Developing new fungicides with novel structures and modes of action is an effective measure to solve this problem.
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