Quinidine-induced gastric ulcer.

Gastrointest Endosc

Madigan Army Medical Center, Tacoma, WA 98341, USA.

Published: September 2004

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http://dx.doi.org/10.1016/s0016-5107(04)01716-xDOI Listing

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The effects of quinidine, an antiarrhythmic alkaloid, on potassium-selective channels in enzymatically dissociated gastric smooth muscle cells from Rana pipiens and Bufo marinus were investigated using excised patches and the patch-clamp technique. The predominant potassium channel in these cells is the calcium- and voltage-activated maxi-K channel with a single-channel conductance greater than 100 pS. Applications of quinidine (100-600 microM) resulted in resolvable rapid flickerings between the open and blocked states with a corresponding reduction in open channel amplitude and an increase in open channel noise.

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