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http://dx.doi.org/10.1016/s0016-5107(04)01716-x | DOI Listing |
Gastrointest Endosc
September 2004
Madigan Army Medical Center, Tacoma, WA 98341, USA.
Pflugers Arch
August 1989
Department of Physiology, Baylor College of Dentistry, Dallas, TX 75246.
The effects of quinidine, an antiarrhythmic alkaloid, on potassium-selective channels in enzymatically dissociated gastric smooth muscle cells from Rana pipiens and Bufo marinus were investigated using excised patches and the patch-clamp technique. The predominant potassium channel in these cells is the calcium- and voltage-activated maxi-K channel with a single-channel conductance greater than 100 pS. Applications of quinidine (100-600 microM) resulted in resolvable rapid flickerings between the open and blocked states with a corresponding reduction in open channel amplitude and an increase in open channel noise.
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