A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans. | LitMetric
Browse Categories

Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans.

Anne-Marie Faucher Murray D Bailey Pierre L Beaulieu Christian Brochu Jean-Simon Duceppe Jean-Marie Ferland Elise Ghiro Vida Gorys Ted Halmos Stephen H Kawai Martin Poirier Bruno Simoneau Youla S Tsantrizos Montse Llinàs-Brunet

Org Lett

Chemistry Department, Boehringer Ingelheim (Canada) Ltd., Research and Development, 2100 Cunard Street, Laval, Québec, Canada H7S 2G5.

Published: August 2004

The synthesis of BILN 2061, an NS3 protease inhibitor with proven antiviral effect in humans, was accomplished in a convergent manner from four building blocks. The procedure described here was suitable for the preparation of multigram quantities of BILN 2061 for preclinical pharmacological evaluation.

Download full-text PDF

 Source
http://dx.doi.org/10.1021/ol0489907DOI Listing

Publication Analysis

Top Keywords

biln 2061
12
synthesis biln
8
ns3 protease
8
protease inhibitor
8
inhibitor proven
8
proven antiviral
8
antiviral humans
8
2061 hcv
4
hcv ns3
4
humans synthesis
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

Privacy Policy Site Map

© LitMetric 2025. All rights reserved.