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Aligning antimicrobial resistance surveillance with schistosomiasis research: an interlinked One Health approach.
Trans R Soc Trop Med Hyg
August 2024
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
One Health surveillance involves the analysis of human, animal and environmental samples, recognising their interconnectedness in health systems. Such considerations are crucial to investigate the transmission of many pathogens, including drug-resistant bacteria and parasites. The highest rates of antimicrobial resistance (AMR)-associated deaths are observed in sub-Saharan Africa, where concurrently the waterborne parasitic disease schistosomiasis can be highly endemic in both humans and animals.
View Article and Find Full Text PDFInter-phylum circulation of a beta-lactamase-encoding gene: a rare but observable event.
Antimicrob Agents Chemother
April 2024
Université Paris Cité, INSERM, Université Sorbonne Paris Nord, IAME, Paris, France.
Beta-lactamase-mediated degradation of beta-lactams is the most common mechanism of beta-lactam resistance in Gram-negative bacteria. Beta-lactamase-encoding genes can be transferred between closely related bacteria, but spontaneous inter-phylum transfers (between distantly related bacteria) have never been reported. Here, we describe an extended-spectrum beta-lactamase (ESBL)-encoding gene () shared between the Pseudomonadota and Bacteroidota phyla.
View Article and Find Full Text PDFCharacterization of Carbapenemase- and ESBL-Producing Gram-Negative Bacilli Isolated from Patients with Urinary Tract and Bloodstream Infections.
Antibiotics (Basel)
August 2023
College of Arts & Sciences, University of Dayton, Dayton, OH 45469, USA.
A total of 199 Gram-negative bacterial isolates from urinary tract infections and 162 from bloodstream infections were collected from 12 healthcare systems throughout the United States between May 2021 and August 2022. The isolates, phenotypically non-susceptible to 2nd or 3rd generation cephalosporins or carbapenems, were characterized through antimicrobial susceptibility testing and whole genome sequence analysis to obtain a broad snapshot of beta-lactamase-mediated resistance among these two sample types. Overall, 23 different carbapenemase genes were detected among 13 species (20.
View Article and Find Full Text PDFMolecular Characterization of Carbapenem-Resistant Isolated from Intensive Care Unit Patients in Jordanian Hospitals.
Antibiotics (Basel)
June 2022
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.
Article Synopsis
- Healthcare-associated infections (HAIs) are significantly associated with multidrug-resistant (MDR) strains primarily found in intensive care units (ICUs) in Jordan.
- Extended-spectrum beta-lactamase (ESBL)-positive isolates show high resistance to essential antibiotics, including carbapenems, mainly due to β-lactamase-mediated mechanisms.
- Out of 120 clinical isolates studied, 95% were MDR, with significant resistance to antibiotics like piperacillin and cephalosporins, highlighting a concerning trend in antibiotic resistance in these hospital settings.
Detailed investigation of catalytically important residues of class A β-lactamase.
J Biomol Struct Dyn
March 2023
Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Jhalwa, Uttar Pradesh, India.
An increasing global health challenge is antimicrobial resistance. Bacterial infections are often treated by using β-lactam antibiotics. But several resistance mechanisms have evolved in clinically mutated bacteria, which results in resistance against such antibiotics.
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