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Coordinated regulation of eosinophil production and migration by glucocorticoids, prostaglandins, and cysteinyl-leukotrienes.
Int Immunopharmacol
January 2025
Laboratório de Citocinas Dept. of Immunology Instituto de Microbiologia Prof. Paulo de Góes Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil.
Introduction: The spectrum of eosinophil functions has expanded from fighting helminths to multiple novel roles in malignancy, infection, cancer, and metabolism. In asthma, glucocorticoids, prostaglandins (PG), and cysteinyl-leukotrienes (LT) regulate eosinophil biology through separate signaling pathways. Here we've evaluated the complex interplay between Dexa, PGE2, and CysLTs in eosinopoiesis and eosinophil biology in an allergic asthma model.
View Article and Find Full Text PDFDexamethasone and IFN-γ primed mesenchymal stem cells conditioned media immunomodulates aberrant NETosis in SLE via PGE2 and IDO.
Front Immunol
November 2024
Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, India.
Background: Systemic Lupus Erythematosus (SLE) is characterized by dysregulated immune responses, with neutrophil extracellular traps (NETs) playing a significant role. NETs are recognized by autoantibodies in SLE patients, exacerbating pathology. Both excessive NET formation and impaired degradation contribute to SLE pathophysiology.
View Article and Find Full Text PDFComparative targeted lipidomics between serum and cerebrospinal fluid of multiple sclerosis patients shows sex and age-specific differences of endocannabinoids and glucocorticoids.
Acta Neuropathol Commun
October 2024
Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern, 3012, Switzerland.
Article Synopsis
- Multiple sclerosis (MS) is a chronic disease marked by the loss of myelin, leading to neurological problems, and the endocannabinoid system (ECS) is being explored as a potential treatment target.
- A study involving 74 MS patients and 80 controls analyzed lipid levels in cerebrospinal fluid (CSF) and serum, revealing that most lipidomic changes in MS do not match between these two fluids.
- Findings showed that specific lipids, including endocannabinoids, varied by sex and age, emphasizing the need to study eCBs in CSF instead of blood to better understand MS-related changes.
The dual role of glucocorticoid regeneration in inflammation at parturition.
Front Immunol
September 2024
Department of Obstetrics, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Introduction: Fetal membrane inflammation is an integral event of parturition. However, excessive pro-inflammatory cytokines can impose threats to the fetus. Coincidentally, the fetal membranes express abundant 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which generates biologically active cortisol to promote labor through induction of prostaglandin synthesis.
View Article and Find Full Text PDFSex differences in the transcriptional response to acute inflammatory challenge: A randomized controlled trial of endotoxin.
Brain Behav Immun Health
October 2024
Norman Cousins Center for Psychoneuroimmunology, UCLA, USA.
Background: Sex differences in immune-based disorders are well-established, with female sex associated with a markedly heightened risk of autoimmune disease. Female sex is also overrepresented in other conditions associated with elevated inflammation, including depression, chronic pain, and chronic fatigue. The mechanisms underlying these disparities are unclear.
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