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Distribution of amphotericin B-arabinogalactan conjugate in mouse tissue and its therapeutic efficacy against murine aspergillosis. | LitMetric
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Distribution of amphotericin B-arabinogalactan conjugate in mouse tissue and its therapeutic efficacy against murine aspergillosis.

Rama Falk Jacob Grunwald Amnon Hoffman Abraham J Domb Itzhack Polacheck

Antimicrob Agents Chemother

Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, P.O. Box 12000, Jerusalem 91120, Israel.

Published: September 2004

The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514765PMC
http://dx.doi.org/10.1128/AAC.48.9.3606-3609.2004DOI Listing

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